胱抑素C在早期肾功能损伤的诊断价值

Diagnostic value of cystatin C on the early renal damage

目的对胱抑素C(Cys C)在临床诊断早期肾功能损伤中的价值进行探讨。方法回顾分析该院2011年6月至2013年6月收治的140例慢性肾功能衰竭患者。采用免疫比浊法对其血清中的Cys C、尿β2-微球蛋白和血清肌酐水平进行检测,并与140例健康者的各项指标进行对比分析。结果 2组研究对象的性别、年龄差异无统计学意义(P>0.05);肾功能损伤患者血清中Cys C、尿β2-微球蛋白和血清肌酐水平都显著低于健康者,差异有统计学意义(P<0.05);而Cys C水平在患者中的特异性以及灵敏度显著大于尿β2-微球蛋白和血清肌酐,差异有统计学意义(P<0.05)。结论患者血清中Cys C水平具有很好的特异性以及灵敏度,能够及时、准确地对患者的肾功能损伤进行评估,对早期肾功能损害的诊断具有临床价值。

Objective To discuss clinical value of cystatin C （Cys C） in the diagnosis of early renal damage . Methods Retrospective analysis the data of 140 cases of chronic renal failure patients treated in our hospital from 2011 June to 2013 June .Cys C ,urinary β2-microglobulin and creatinine levels in serum were detected ,the indicators of those in early renal damage and healthycontrols were analyzed ,and compared .Results Two groups had no signifi-cant difference in gender ,age（P〉0 .05） .The levels of Cys C in serum ,the urineβ2-microglobulin and serum creati in patiens of renal function injury were significantly lower than those of healthy subjects （P〈0 .05） .Specificity and sen-sitivity of Cys C were more significant than those of urine β2-microglobulin and serum creatinine（P〈0 .05） .Conclu-sion The serum Cys C levels in patients has good specificity and sensitivity ,injury on renal function of patients was evaluated ,timely ,accurateiy by Cys C ,Cys C is of great value in diagnosis of early renal dama .