晚发型抑郁症患者脑白质胆碱能通路的磁共振研究

An MRI Study of Cholinergic Pathway of Cerebral White Matter in Patients with Late-onset Depression

目的探讨晚发型抑郁症患者脑白质胆碱能通路的改变及其与认知功能障碍的关系。方法晚发型抑郁症患者(患者组,n=20)行磁共振检查,采用胆碱能通路高信号评分(CHIPS)评估患者脑白质胆碱能通路的改变、采用蒙特利尔认知评估量表(MoCA)评定认知功能,并与正常老年人(对照组,n=20)进行对照。结果①患者组CHIPS评分显著高于对照组、MoCA评分显著低于对照组,差异均有统计学意义(t=3.119,3.025;P=0.0032,0.0044);②患者组、对照组的CHIPS评分均与MoCA评分负相关(r=-0.490,-0.482;P=0.026,0.038)。结论晚发型抑郁症患者存在脑白质胆碱能通路受损,并与患者的认知功能改变有关。

Objective To assess the extent of the damage to cholinergic pathway of cerebral white matter in patients with late -onset depression and explore its association with cognitive disorder .Methods MRI tests were carried out on patients with late-onset depres-sion（case group,n=20） and normal elderly people（control group,n=20） respectively.Cholinergic Pathways Hyperintensities Scale （ CHIPS） was used for damage assessment of cholinergic pathway of cerebral white matter ,while Montreal Cognitive Assessment （ MoCA） for cognitive disorder assessment .Results The CHIPS score of the case group was significantly higher than that of the control group （ t=3.119,P〈0.01）,and the MoCA score of the case group was significantly lower than that of the control group （t=3.025,P〈0.01）;The CHIPS score negatively correlated with the MoCA score in both groups （r=-0.490,-0.482;P〈0.05）.Conclusion The cholinergic pathway of cerebral white matter in patients with late-onset depression is damaged to a certain degree ,which might play a role in cognitive disorder.