经安汤治疗经前期综合征临床对照观察

Controlled Clinical Observation of Jinga'ntang in Treatment of Premenstrual Syndrome

目的探讨经安汤治疗经前期综合征(PMS)的临床疗效与安全性。方法将100例PMS患者随机分入试验组和对照组各组50例,分别给予经安汤和舍曲林+维生素B6治疗,连续治疗3个月经周期。采用症状量化评分法评定临床疗效,用汉密顿焦虑量表(HAMA)和副反应量表(TESS)分别评定患者情绪和不良反应。结果治疗后两组HAMA和症状评分均较治疗前显著下降,但试验组减分幅度大于对照组(t=2.818,3.350,1.214,4.449,3.233,2.891;P=0.006,0.001,0.228,0.000,0.002,0.005);临床疗效优于对照组(Z=-1.844,-2.385,-2.547;P=0.065,0.017,0.011);复发率和不良反应发生率低于对照组(χ2=4.882,6.250;P=0.027,0.012)。结论经安汤治疗经前期综合征疗效确切,安全性好,优于舍曲林+维生素B6治疗。

Objective To explore the clinical efficacy and safety of Jing ＇antang in the treatment of premenstrual syndrome .Methods All 100 patients with the premenstrual syndrome were randomly assigned to test groups and control group .Each had 50 cases.The patientswere treated with Jingantang or sertraline and vitamin B6 respectively for 3 months.The symptoms quantitative evaluation methodwas used to evaluate the clinical efficacy .Hamilton Anxiety Scale（HAMA） and Treatment Emergent Symptom Scale（TESS） were used toevaluate the patients＇mood and adverse effect respectively.Results The scores of HAMA and the symptoms after the treatment were sig -nificantly lower than those before the treatment in both groups .But the decrease range of those scores in the test group was significantlygreater than those in the control group （t =2.818,3.350,1.214,4.449,3.233,2.891;P =0.006,0.001,0.228,0.000,0.002 and0.005）.The clinical efficacy in the test group was significantly better than that in the control group （Z =-1.844,-2.385,,-2.547;P =0.011,0.012 ,0.045）.The rates of the relapse and adverse effect in the test group were significantly lower than those in the controlgroup（χ2 =4.882,6.250;P =0.027,0.012）.Conclusion Jing＇antang is efficient and safe in the treatment of the premenstrual syn -drome.It is better than sertraline and vitamin B6.