应用中医“四时”理论探讨地中海贫血的治疗思路

Discussion on Treating Thalassemia From Four-Season Theory in Chinese Medicine

《黄帝内经》提出人身阴阳与四时阴阳存在协调同步的变化,人体的生命运动、病理状态具有时间周期性及节律性,"四时"与人体疾病的发生、发展及康复有着密不可分的联系。阐述了中医"四时"理论的科学内涵和"四时"对疾病的影响,重点论述了季节变化对地中海贫血患者的影响。地中海贫血患者在高温季节溶血严重,低温季节有所缓解,血红蛋白水平与气温呈负相关;地中海贫血患者多表现为肝肾阴虚、精血不足证,患者在高温季节阴虚症状表现较重,因此尝试在益髓生血颗粒原方基础上加麦冬治疗,取得了良好的疗效。提示在治疗疾病时,应考虑环境因素,顺应"四时"的季节变化,进行适时治疗。

Huangdi Neijing （Inner Canon of Huangdi） points out that yin-yang of the body is synchronized with yin-yang of four-season. Llife activities and pathological conditions have the time period and rhythm and four-season is inextricably linked to the occurrence, development and rehabilitation of disease. The scientific connotation of Four- Season Theory in Chinese medicine and the impact of four-season on disease especially the impact of seasonal varia- tions on thalassemia were discussed in this article. Severe hemolysis is very common in the hot season in thalassemia patients. The hemoglobin level is negatively correlated with air temperature. Most thalassemia patients manifest liver- kidney yin deficiency syndrome and essence-blood deficiency syndrome. Thalassemia patients manifest severe symp- toms of yin deficiency syndrome in the hot season. Therefore, we added Maidong （Radix Ophiopogonis, ~ ） in Yisui Shengxue Granules and achieved good efficacy. Environmental factors and seasonal changes should be consid- ered in treatment for thalassemia.