CRP和Cys C联合检测对痛风患者早期肾损伤的诊断价值

Diagnostic value of combined detection of serumCRP and Cys C for early renal injury in gouty patients

目的探究联合检测C-反应蛋白(CRP)和胱抑素C(Cys C)对痛风患者早期肾损伤的诊断价值。方法选取2010年6月至2013年6月我院收治的260例痛风患者,按照是否伴有早期肾损伤分为A组(伴有早期肾损伤组)B组(未伴有早期损伤组)各130例,检测与对比两组患者的CRP与Cys C水平。结果 A组CRP、Cys C水平均显著高于B组,肾小球滤过率显著低于B组,差异具有统计学意义(P<0.05);A组患者的CRP与Cys C联合检测的阳性率均显著高于CRP单独检测阳性率与Cys C单独检测阳性率,差异具有统计学意义(P<0.05),而CRP与Cys C阳性率对比,差异不具有统计学意义(P>0.05);CRP与Cys C联合检测的敏感度与特异度分别为88.9%与84.9%。结论对痛风患者进行CRP与Cys C联合检测,能够有效提高早期肾损伤的阳性检出率,增加诊断可靠性,具有临床推广价值。

Objective To explore the the diagnostic significance of combined detection of serum C reactive protein （CRP） and cystatin C （Cys C） for early renal injury in gouty patients. Methods 260 cases of gouty patients were divided into 2 groups：group A （with early renal damage group, n=130）, group B （without early renal damage group, n=130）, the serum CRP and Cys C from two groups were measured and compared respectively. Results The levels of CRP and Cys C in group A were significantly higher than those group B （P〈0.05）. The positive rate of CRP and Cys C combined detection in group A was significantly higher than those in group B （P〈0.05）. Comparing the pos- itive ratio of CRP or Cys C in two groups respectively, there were no obvious difference in statistic （P〉0.05）. The sensitivity rate and specificity rate of combination detection of CRP and Cys C were 88.9% and 84.9% respectively. Conclusion Simultaneous determination of serum CRP and Cys C can help to assess the early renal injury in pa- tients with gout, and increase the diagnostic reliability, which is worthy of clinical application.