脂微球载体前列腺素E_1治疗儿童急性肾损伤的疗效评价

Effect of prostaglandin E_1 on acute kidney injury in children

目的观察前列腺素E1(PGE1)治疗儿童急性肾损伤(AKI)的临床效果。方法将52例急性肾损伤患儿随机分为3组,1组:单纯PGE1治疗,18例;2组:多巴胺、酚妥拉明联合治疗,17例;3组:PGE1、多巴胺及酚妥拉明联合治疗,17例。观察三组治疗前后血肌酐(Scr)、24 h尿蛋白定量、尿红细胞数、血、尿β2-微球蛋白(β2-MG)的变化。结果治疗2周后,各组间患儿治疗后血肌酐、24 h尿蛋白定量及尿红细胞数差异有统计学意义(分别为F1=6.86,F2=6.9,F3=5.59,P均<0.05),各组间血、尿β2-MG差异无统计学意义(F4=1.32,F5=0.79,P>0.05),其中1组和3组治疗后血肌酐及尿红细胞下降明显优于2组治疗后(P<0.05)。结论前列腺素E1具有加快肾功能改善、减少尿蛋白及血尿的作用,治疗儿童AKI优于传统的方法,具有较好的临床疗效。

Objective To study the clinical effect of prostaglandin E1on acute kidney injury（ AKI） in children.Methods 52 children with AKI were randomly divided into three groups： group 1（ 18 cases） was treated with prostaglandin El,group 2（ 17 cases） was treated with dopamine and phentolamine,both prostaglandin and dopamine phentolamine were given to group 3（ 17 cases）. Serum creatinine,24 hours＇ urine protein,urinalysis RBC,blood and urine β2-microglobulin were observed. Results After 2 weeks treatment,there were significant differences in serum creatinine,24hours＇ urine protein and urinalysis RBC among the three groups after treatment（ F1= 6. 86,F2= 6. 9,F3= 5. 59,P〈0. 05）,but there were no significant difference in blood and urine β2-microglobulin（ F4= 1. 32,F5= 0. 79,P〉0. 05）,The serum creatinine and urinalysis RBC in group 3 after treatment decreased better than that in group 2（ P〈0. 05）.Conclusion Prostaglandin E1can promote the improvement of renal function and reduce the urine protein and hematuresis. The clinical effect of prostaglandin E1on acute kidney injury in children is better than traditional treatment.