三种化疗方法治疗晚期胃癌的生存分析

Survival analysis of three kinds of chemotherapy for advanced gastric cancer

目的研究三种化疗方法对晚期胃癌生存时间的影响。方法将未经手术同时有病理学诊断依据的28例患者分为以紫杉醇、奥沙利铂和顺铂为主的化疗方案3个小组,治疗期间观察患者的生存时间,采用Kaplan-Meier法对组间进行比较,采用Cox回归模型对相关影响因素进行分析。结果三种化疗方案对患者的生存时间有影响(P<0.05),组间比较显示,接受紫杉醇为主化疗和奥沙利铂为主化疗的患者的生存时间比接受顺铂为主化疗的患者长。多因素Cox回归显示,"从确诊到化疗时间"和"治疗方案"是延长患者生存时间的主要因素,选择正确的治疗方案可以降低患者近期死亡风险2.15倍,早期进行化疗可以降低患者近期死亡风险0.68倍。结论选用奥沙利铂或紫杉醇为主的化疗方案较好,同时要对确诊患者尽早进行化疗。

Objective To study the effect of three kinds of chemotherapy for the survival time of advanced gastric cancer. Methods A total of 28 advanced gastric cancer patients who were confirmed pathologically and without surgery were randomized to paclitaxel group,oxaliplatin group and cisplatin group,during treatment we observed the patient＇s survival time,and then using the Kaplan-Meier method for comparison between the groups,using Cox regression model to analyze the relevant factors. Results Three kinds of chemotherapy regimens had effect on survival time of the patients（ P〈0. 05）,that patients received paclitaxel-based chemotherapy and with oxaliplatin-based chemotherapy had long survival time than patients receiving cisplatin-based chemotherapy. Cox regression analysis showed that＂the time from diagnosis to chemotherapy＂and＂chemotherapy regimens＂were the main factors to extend the survival time,and selecting the right treatment could reduce the risk of death in patients with recent 2. 15 times,early chemotherapy could reduce the risk of death in patients with recent 0. 68 times. Conclusion The use of oxaliplatin or paclitaxel-based chemotherapy is better,while chemotherapy for patients diagnosed as early as possible.