对乙酰氨基酚预防唑来膦酸不良反应用药时机的探讨

Probe into medication timing of acetaminophen for prevention of zoledronic acid adverse reaction

[目的]探讨对乙酰氨基酚预防唑来膦酸注射液(密固达)不良反应最佳用药时机。[方法]将60例绝经后骨质疏松症病人随机分入观察组和对照组,每组30例。观察组静脉输注唑来膦酸注射液前1h,对照组在静脉输注后1h给予口服对乙酰氨基酚缓释片,两组间隔6h后和次日再分别给药1次。用副反应量表(TESS)评定不良反应。[结果]在使用唑来膦酸注射液后4h、8h和第2日3个评分时段,观察组TESS评分低于对照组(t=-7.087,-4.777和-5.087,P均<0.01)。[结论]在静脉输注唑来膦酸注射液前使用对乙酰氨基酚,能有效预防唑来膦酸不良反应,效果优于静脉输注后给药。

Objective. To probe into the best medication timing of acetaminophen for prevention of zoledronic acid adverse reaction. Methods：A total of 60 cases of patients with postmenopausal osteoporosis were randomly divided into observation group and control group,30 cases in each. At 1 h before intravenous infusion of zoledronic acid injection in observation group and at 1 h after intravenous infusion in control group, the patients were given oral acetaminophen sustained release tablets, oral acetaminophen were administered once again respectively after interval 6 h and the next day in two groups. The adverse reactions were evaluated with TESS （TESS）. Results. three ratings periods including 4 h, 8h and the 2nd day after the use of zoledronic acid injection, the TESS score in observation group was lower than that in control group （t=- 7. 087,-4. 777 and -5. 087,P〈0.01）. Conclusion.acetaminophen used before intravenous infusion of zoledronic acid injection using can effectively prevent adverse effects of zoledronic acid,and its effect is better than that after intravenous administration.