摘要
[目的]探讨对乙酰氨基酚预防唑来膦酸注射液(密固达)不良反应最佳用药时机。[方法]将60例绝经后骨质疏松症病人随机分入观察组和对照组,每组30例。观察组静脉输注唑来膦酸注射液前1h,对照组在静脉输注后1h给予口服对乙酰氨基酚缓释片,两组间隔6h后和次日再分别给药1次。用副反应量表(TESS)评定不良反应。[结果]在使用唑来膦酸注射液后4h、8h和第2日3个评分时段,观察组TESS评分低于对照组(t=-7.087,-4.777和-5.087,P均<0.01)。[结论]在静脉输注唑来膦酸注射液前使用对乙酰氨基酚,能有效预防唑来膦酸不良反应,效果优于静脉输注后给药。
Objective. To probe into the best medication timing of acetaminophen for prevention of zoledronic acid adverse reaction. Methods:A total of 60 cases of patients with postmenopausal osteoporosis were randomly divided into observation group and control group,30 cases in each. At 1 h before intravenous infusion of zoledronic acid injection in observation group and at 1 h after intravenous infusion in control group, the patients were given oral acetaminophen sustained release tablets, oral acetaminophen were administered once again respectively after interval 6 h and the next day in two groups. The adverse reactions were evaluated with TESS (TESS). Results. three ratings periods including 4 h, 8h and the 2nd day after the use of zoledronic acid injection, the TESS score in observation group was lower than that in control group (t=- 7. 087,-4. 777 and -5. 087,P〈0.01). Conclusion.acetaminophen used before intravenous infusion of zoledronic acid injection using can effectively prevent adverse effects of zoledronic acid,and its effect is better than that after intravenous administration.
出处
《全科护理》
2014年第16期1441-1442,共2页
Chinese General Practice Nursing
基金
广东省自然科学基金项目
编号:S2012040006890