婴儿痉挛症脑干信息传导障碍的混沌学研究

CHAOTIC CHARACTERISTIC OF BRAINSTEM INFORMATION CONDUCTIVE OBSTRUCTION IN INFANTILE SPASMS

:婴儿痉挛症 (InfantileSpasms,IS)是婴幼儿难治性癫痫。IS的发病机理至今也不清楚 ,目前比较一致的假说是 :脑干是IS的责任结构 ,但该假说不能用神经生理学的传统方法来证实。从信息学的角度 ,婴儿痉挛症的发病机制可能是源自脑干神经信息传递障碍的脑干功能失调。为了证实这一论点 ,用可以反映脑干传导功能的听觉诱发响应的相关维数 ,来评估脑干神经信息传导不同的功能状态。经过对IS患者、颞叶癫痫患者和健康人三个组的结果比较分析 ,表明IS患者脑干听觉诱发响应的相关维数明显低下 ,而颞叶癫痫患者该相关维数在颞叶病灶处最低。以上结果 ,证实了IS患者脑干神经信息传导功能障碍的存在。

Infantile spasms(IS) is one of epilepsy in children with physical and intellective maldevelopment. Its pathogenesis is unknown. At present, one of concurrent hypothesis about the pathogenesis of IS is only that brainstem is the responsible structure of IS. But this hypothesis can not been proved by traditional neurophysiological method. In this study, the pathogenesis of IS is investigated with the point of view of information science, the pathogenesis of IS is that brainstem dysfunction results from neural information conductive obstruction in brainstem. The correlation dimension of auditory evoked brain waves are estimated and compared to judge information conductive function in brainstem. In contrast to temporal lobar epilepsy patients(TLEP), correlation dimension at the auditory area in infantile spasm group is obviously low. This result demonstrates that the information conductive obstruction exist in brainstem of infantile spasm patients.