2型糖尿病患者同型半胱氨酸与左心室射血分数相关性研究

Correlation analysis on serum homocysteine and left ventricular ejection fraction in type 2 diabetes mellitus

目的：近年有许多关于同型半胱氨酸（Hcy）与左心室射血分数（LVEF）相关性的研究。但在2型糖尿病患者中，两者关系仍不清楚。本研究将评估2型糖尿病患者Hcy与LVEF的相关性。方法选择2型糖尿病患者72例，按是否合并冠心病分为两组，均检测血Hcy、糖化血红蛋白、甘油三酯（TG）、总胆固醇（TC）等水平。心脏超声评估LVEF。结果两组患者收缩压、舒张压、糖化血红蛋白、TC及TG比较均无统计学意义（P＞0.05）；糖尿病合并冠心病组Hcy明显高于单纯糖尿病组，差异具有统计学意义（P ＜0.05）；Hcy是糖尿病合并冠心病组LVEF＜55％的危险因素[OR＝1.211（95%CI 1.041-1.408）]；糖尿病合并冠心病组患者血 Hcy 水平与LVEF 明显负相关（r=-0.706，P=0.000）。结论2型糖尿病患者血清Hcy与LVEF呈负相关，Hcy是2型糖尿病合并冠心病患者LVEF＜55％的危险因素。

Objective A link between homocysteine （Hcy） and left ventricular ejection fraction（LVEF） emerged from re-cent studies but was yet not explored specifically in type 2 diabetic patients. This study aimed to assess the relationship between LVEF and Hcy in type 2 diabetic patients. Methods A total of 72 type 2 diabetic patients were selected for this study and were divided into two groups （40 examples with coronary heart disease, 32 examples without coronary heart disease） javascript：Serum Hcy,glycosylated hemoglobin,cholesterol（TC） and triglyceride（TG） were analyzed.LVEF was assessed by echocardiography. Results There was no difference in systolic blood pressure, diastolic blood pressure, glycosylated hemoglobin,total cholesterol and triglyceride in two groups of patients （P〉0.05）;The serum Hcy was obvi-ously higher in type 2 diabetic patients with coronary heart disease compared to those without （P〈0.05）;Factors signifi-cantly associated with a LVEF〈55%were serum Hcy OR=1.211（95%CI 1.041-1.408） in type 2 diabetic patients with coronary heart disease.The serum Hcy had significant negatively correlation with LVEF （r=-0.706,P=0.000） in type 2 diabetic patients with coronary heart disease. Conclusion This study highlights an inverse relationship between Hcy and LVEF in type 2 diabetic patients with coronary artery disease.The serum Hcy is a risk factor associated with a LVEF〈55%.