地佐辛复合舒芬太尼对结直肠癌患者术后镇痛效果的研究

Study on the postoperative analgesic effect of dezocine and sufentanil in patients with colorectal cancer

目的：探讨地佐辛复合舒芬太尼对结直肠癌患者术后镇痛效果。方法选取2011年1月-2013年6月于本医院治疗的择期行结肠癌、直肠癌根治手术患者68例，随机分为对照组和观察组，每组34例，对照组患者术后给予单纯的舒芬太尼镇痛，观察组患者术后给予地佐辛复合舒芬太尼给患者镇痛，比较两组患者的2h，6h，12h，24h，48 h的VAS和Ramsay镇静评分及镇痛期间的不良反应发生率。结果两组患者的性别比例、年龄分布、体重、ASA分级、手术时间的差异均无统计学意义（P〉0.05）；两组患者的不同时间点的VAS评分比较的差异均无统计学意义（P〉0.05）；两组患者的不同时间点的Ramsay评分比较的差异均具有统计学意义（P〈0.05）；两组患者镇痛期间的不良反应发生率（嗜睡、恶心呕吐和尿潴留）的差异具有统计学意义（P〈0.05）。结论采用地佐辛复合舒芬太尼对结直肠癌患者术后镇痛效果明显，临床不良反应较少，安全性较好，且明显优于单纯舒芬太尼的临床应用效果，值得临床推广。

Objective To investigate the postoperative analgesic effect of dezocine and sufentanil in patients with col-orectal cancer. Methods Sixty-eight cases with colon cancer, rectal cancer undergoing radical operation in our hospital from January 2011 to June 2013, were randomLy divided into control group and observation group, 34 patients in each group, the patients in control group were given sufentanil analgesia after surgery, and patients in the observation group were given dezocine and sufentanil for analgesia. The VAS and Ramsay sedation score in 2h, 6h, 12h, 24h, 48h and the incidence ratio of adverse reaction during analgesia were compared in two groups. Results There was no statistical significance in the difference of the two groups of sex ratio, age distribution, body weight, ASA classification （P〉0.05）;there was no significnt difference in VAS scores between the two groups at different time points （P〉0.05）;There were statistically significant in differences of Ramsay scores among different time points of two groups （P〈0.05）;There were statistically significant in differences of the incidence ratio of adverse reaction of two groups during analgesia （drowsiness, nausea and vomiting, urinary retention） （P〈0.05）. Conclusion Analgesic effect of using dezocine and sufentanil with less adverse reaction, good safety is obvious better than sufentanil only in the patients with colorectal cancer after operation, and is worth the clinical promotion.