凝血功能对急性肾功能衰竭早期检测的意义

The value of blood coagulation function in early stage of acute renal failure

目的：探讨凝血功能在早期急性肾功能衰竭中的变化，说明凝血功能在急性肾功能衰竭中的意义。方法选择2011年10月-2014年3月粤北人民医院肾内科和儿科收治的急性肾功能衰竭患者80例为观察组，同期体检中心健康体检者50例为对照组，比较两组肌酐、尿素氮、血小板、活化部分凝血活酶时间（APTT）、凝血酶原时间（PT）、凝血酶时间（TT）、血浆纤维蛋白原（FIB）的水平。结果观察组FIB、血小板水平明显高于对照组（P＜0.05），而APTT、PT、TT差异无统计学意义（P＞0.05）。结论早期急性肾功能衰竭患者血液呈高凝状态，凝血功能异常可能参与急性肾功能衰竭的形成。

Objective To study the changes of blood coagulation function in early stage of acute renal failure patients, and illustrate its significance. Methods From October 2011 through January 2013, 80 patients with acute renal failure in the Nephrology Department and Pediatrics Department of Yuebei People’s Hospital were enrolled in this study,50 health people in the same period as control group,then compare the differences in creatinine, blood urea nitrogen, blood platelet（PLT）, activated partial thromboplastin time（APTT）, prothrombin time（PT）, thrombin time（TT）, plas-ma fibrinogen （FIB） between the two groups. Results The FIB levels and PLT count in observation group were higher than those of controls group （P〈0.05）, but APTT,PT,TT showed no statistically significant difference （P〉0.05）. Con-clusion Hypercoagulabale state could occur in patients with acute renal failure in early stage, abnormal clotting may be participates in occurrence of acute renal failure.