急性缺血性中风早期中小剂量溶栓治疗的初步研究

The Preliminary Study of Thrombolysis on Acute Ischemic Stroke with Mid minidose Urokinase

目的 研究用中、小剂量尿激酶 ( UK)溶栓治疗急性缺血性中风的临床效果 ,寻找一个安全的适合静脉溶栓的 UK剂量和方法。 方法 将急性缺血性中风患者分为两组 :溶栓组 1 8例 ,中小剂量 UK溶栓 ,视病情变化予以追加。常规治疗组 (对照组 ) 1 2例 ,除不用 UK外 ,其它治疗措施相同。每例患者于治疗前后进行欧洲卒中量表 ( ESS)评分 ,以评价疗效。 结果 溶栓组溶栓后 2 h、 6 h、 1天、 2天、 3天、 7天和 1 4天的 ESS评分均比溶栓前升高 ,无并发出血现象。溶栓组治疗后第 1天、第 2天、第 3天、第 7天和第 1 4天 ESS评分与治疗前 ESS评分的差值明显高于常规治疗组治疗后第 1天、第 2天、第 3天、第 7天和第 1 4天 ESS评分与治疗前 ESS评分的差值。 结论 用中小剂量 UK溶栓 ,实行剂量个体化 ,效果较好 。

Objective To study the thrombolysis of acute ischemic stroke with urokinase(UK),and to observe the clinical efficacy,looking for a safe dosage and a way fit for thrombolysis via vein Method Thrombolysis of 18 cases of acute ischemic stroke were performed with mid minidose of UK The therapy of the control group was the same as the group of thrombolysis except for not using UK Every case was scored with Europe stroke scale before and after thrombolysis and the scores were subjected to statistics to evaluat the efficacy Results The scores of ESS are higher than those before thrombolysis at the second hour,the sixth hour,the first day,the second day,the third day,the seventh day and the fourteenth day after thrombolysis The subjectives had no hemorrhage The scores of the thrombolysis group were much higher than those of control group Conclusion Compared with control group,the efficacy of thrombolysis with mid minidose is better and the side effect less [