盐酸氨溴索注射液治疗AECOPD的效果及安全性分析

The effect and safety analysis of ambroxol hydrochloride in treatment of AECOPD

目的：观察盐酸氨溴索注射液治疗慢性阻塞性肺疾病急性加重（AECOPD）的临床疗效及安全性。方法选取2013年3月~2014年1月于本院进行治疗的AECOPD患者92例，随机分为对照组和观察组，每组46例，对照组采用常规治疗，观察组采用盐酸氨溴索注射液治疗。比较两组的临床疗效和不良反应发生率。结果观察组咳嗽缓解时间、呼吸困难消失时间、啰音消失时间及住院时间分别为（3.4±0.7）、（2.6±0.5）、（3.3±0.9）、（7.2±1.8）d，短于对照组的（5.2±1.4）、（3.7±0.8）、（5.3±1.6）、（9.1±2.4）d，差异有统计学意义（P＜0.05）。观察组治疗总有效率为97.8%，高于对照组的87.0%，差异有统计学意义（P＜0.05）。观察组不良反应发生率为8.7%，对照组不良反应发生率为6.5%，两组差异无统计学意义（P＞0.05）。结论盐酸氨溴索注射液治疗AECOPD效果显著，安全、有效，值得临床推广应用。

Objective To compare the clinical efficacy and safety of ambroxol hydrochloride in the treatment of acute exacerbation of chronic obstructive pulmonary disease （AECOPD）. Methods 92 cases of patients with AECOPD were enrolled in this study and were randomly divided into control group （n=46） and observation group （n=46）,the control group were given with conventional therapy,ambroxol hydrochloride was given to the observation group.The clinical ef-fects and side effects were compared between the two groups. Results The time of cough relief,disappearance of breath difficult,wheeze relief and hospital during was （3.4±0.7）,（2.6±0.5）,（3.3±0.9）,（7.2±1.8） d in observation group respective-ly,shorter than （5.2±1.4）,（3.7±0.8）,（5.3±1.6）,（9.1±2.4） d in control group respectively,the difference was significant be-tween the two groups （P〈0.05）.The total effective rate in observation group was 97.8%,higher than 87.0% of the control group,the difference was significant （P〈0.05）.The rate of clinical adverse reactions in observation was 8.7%,and that was 6.5%of the control group,the difference was not significant between the two groups （P〉0.05）. Conclusion Ambrox-ol hydrochloride is effective in the treatment of AECOPD,it is safe,and is worthy to be popularized in clinic.