纳洛酮治疗脑血栓的临床效果观察

Clinical effect observation of naloxone in treatment of cerebral thrombosis

目的：探讨纳洛酮治疗脑血栓的临床效果。方法选取本院2012年1月~2014年1月收治的脑血栓患者60例，将其随机分为观察组和对照组，观察组在常规治疗的基础上加用纳洛酮治疗，对照组在常规治疗的基础上加用复方丹参治疗，比较两组的治疗效果。结果观察组治疗总有效率为93.3%，高于对照组的76.7%；平均起效时间为（7.65±2.43） d，短于对照组的（10.18±2.65） d；治疗后的 NIHSS 评分为（6.15±1.26）分，低于对照组的（12.48±2.88）分；两组上述指标差异有统计学意义（P＜0.05）。两组治疗期间均未见明显不良反应。结论纳洛酮治疗脑血栓效果显著，对快速改善症状、提高治疗效果、改善预后具有重要作用。

Objective To explore the clinical efficacy of naloxone in the treatment of cerebral thrombosis. Methods 60 cases of patients with cerebral thrombosis admitted and treated in our hospital from January 2012 to January 2014 were selected and randomly divided into observation group and control group.Naloxone was added to the observation group on the basis of conventional treatment and compound salvia miltiorrhiza was added to the control group on the basis of conventional treatment.The therapeutic effects were compared between the two groups. Results In the observation group,the total effective rate was 93.3%,higher than 76.7% of the control group;average onset time was （7.65±2.43） d, shorter than （10.18±2.65） d of the control group;and post-treatment NIHSS score was 6.15±1.26,lower than 12.48±2.88 of the control group;with significant difference （P〈0.05）.There was no significant adverse reaction in the two groups dur-ing treatment. Conclusion Naloxone has significant efficacy for treatment of cerebral thrombosis and plays an important role in improving symptoms,therapeutic effects and prognosis.