人类辅助生殖技术中禁欲时间的相关研究进展

Research progress of abstinence time in human assisted reproductive technology

禁欲时间的长短对精液质量会产生影响已成为共识,多数认为随着禁欲时间延长,精子的活率、活力、前向运动精子百分率降低,精液量、密度及总精子数增加,但具体机制不详;也有认为可能与精子核蛋白转型、精子顶体酶活性及DNA碎片有关。宫腔内人工受精时禁欲时间长短与妊娠率呈负相关,而禁欲时间长短对体外受精-胚胎移植治疗的实验室指标、临床结局是否有影响,目前国内外研究甚少。

It is a consensus that the length of abstinence time will have an impact on semen quality.Most of the litera-ture suggests that with prolonged abstinence time,sperm motility,vitality,the forward movement of sperm will reduce,se-men volume,sperm density and total sperm count will increase.Specific mechanism is unknown.Some literatures sug-gests that it is related to sperm nucleoprotein transition,sperm acrosome activity and DNA fragmentation.Studies have shown that the length of abstinence time was negatively correlated with pregnancy in IUI,but whether it will affect lab-oratory parameters and clinical outcomes in IVF-ET,little research can available at present.