家庭氧疗对存在睡眠呼吸紊乱的稳定期COPD患者的临床研究

Study of oxygen therapy in COPD patients with sleep breathing disturbance

目的 探讨早期介入家庭氧疗对存在睡眠呼吸紊乱的稳定期COPD患者的疗效.方法 将存在睡眠呼吸紊乱（AHI 5～30次/h）的患者138例随机分为实验组和对照组,实验组入组病例69例,对照组入组病例69例.给予实验组中的COPD患者长期家庭氧疗治疗（吸氧流量1～2 L/min,吸氧时间＞15 h/d）＋常规治疗,而对照组中的COPD患者仅常规治疗2年.应用圣乔治呼吸问卷（SGRQ）对两组患者治疗前后进行评分.结果 实验组经长期家庭氧疗治疗2年后SGRQ总评分较前下降,差异具有统计学意义（t＝38.42,P＜0.05）,其中呼吸症状评分、疾病影响评分亦较前下降,差异具有统计学意义（t值分别为26.38、33.73,P值均＜0.05）.对照组治疗2年后SGRQ总评分、呼吸症状评分、活动受限评分、疾病影响评分差异无统计学意义（t值分别为5.22、4.61、2.23、2.781,P值均＞0.05）.结论 长期家庭氧疗是延缓COPD患者病情进展、生活质量得以提高的一种简便、安全、有效的治疗手段.

Objective To observe the therapeutic effect of early domiciliary long-term oxygen therapy （LTOT） on chronic obstructive pulmonary disease （COPD） patients with sleep breathing disturbance.Methods Choose 138 COPD patients with sleep breathing disturbance （AHI 5～30 times/h）,randomly divided into two groups：the experimental group and the control group,each group was 69.Two groups received routine treatment for two years.At the same time the experimental group received family oxygen.St George＆#39;s respiratory questionnaire （SGRQ） scores on two groups of patients before and after treatment.Results After two years,the SGRQ scores of experimental group were significant declinded （t =38.42,P 〈0.05）,among them the scores of respiratory symptoms and disease impact were significant declined （t =26.38,33.73,P 〈 0.05）.The difference of scores for SGRQ,respiratory symptoms,restricted movement and disease impact in control group were not significant different （t =5.22,4.61,2.23,2.781,P 〉0.05）.Conclusions Long-term oxygen therapy for patients with COPD can slow decline of disease,improve the quality of life.