肠原发性非何杰金淋巴瘤与结核杆菌感染

MYCOBACTERIUM TUBERCULSIS INFECTION AND PRIMARY INTESTINAL NON-HODGKIN LYMPHOMA

目的 探讨肠原发性非何杰金淋巴瘤 ( PINHL)与结核杆菌感染的关系。方法 采用聚合酶链反应 ( PCR)技术对 2 0例手术切除的 PINHL的瘤组织和瘤旁粘膜组织进行结核杆菌 DNA( TB-DNA)检测 ,同时回顾临床资料。结果 2 0 %的 PINHL瘤组织和 30 %的瘤旁粘膜组织中检出了 TB-DNA,且发现 TB-DNA阳性病例多是 B细胞性 PINHL ,发病部位多靠近回盲部。结论 结核杆菌感染与 PINHL

Objective To study the relation of mycobacterium tuberculosis infection with primary intestinal Non-Hodgkin lymphoma(PINHL) Methods Tuberculosis DNAs(TB-DNAs)in the tumor tissues and peritumor mucosa tissues of 20 PINHL cases were measured by Polymerase chain reaction(PCR) assay,simultaneously clinical materials were reviewed Result TB-DNAs were detected in tumor tissues of 4 cases(20%) and peritumor mucosa tissues of 5 cases(30%) B cell PINHL mainly existed in TB-DNA positive cases The locations of PINHLs were principally near ileum-cecum Conclusion There was probably a specific association between PINHL and mycobacterium tuberculosis infection