应用生态制剂对肝硬化患者血浆内毒素水平和自发性细菌性腹膜炎发生的影响

EFFECT OF BIFIDOBACDERIUM BIFIDUM AGENTS ON PLASMA ENDOTOXIN AND SPONTANEUS BACTERIAL PERITONTIS IN CIRRHOTIC PATIENTS WITH ASCITES

对肝硬化腹水患者应用双歧杆菌制剂预防原发性腹膜炎效果进行探索。6 8例患者随机分为培菲康组和对照组。入院时两组患者的年龄、诊断、并发症、肝肾功能和凝血酶原活动度比较无显著差异。 6 8例患者共发生原发性腹膜炎 8例 ,其中治疗组 34例中 ,发生 1例 ,发生率为 2 .9% ,对照组 34例发生 7例 ,发生率为 2 0 .6 %。 8例腹膜炎患者中 5例腹水分离出细菌 ,以革兰阴性菌为主 ,其中大肠杆菌 2例。培菲康口服后血浆内毒素水平显著降低。结果表明 。

Objective: To assess the effect of Bifidobacterium biidum agents on plasma endotoxin and in the revention of spontaneous bacterial peritonitis in hospitalized patients with active cirrhosis with ascites Method:68 patients were included in the study Patients in group A (n=34) were received Bifidobacterium bifidum agents The group B (n=34) was control group Results: Spontaneous bacterial peritonitis developed in 1 patients (2 9%) from group A and in 7 patients (20 6%) from group B Incidence of spontaneous bacterial peritonitis was significantly higher in patients with serum bilirubin more than 85 μmol/L and albumin less than 30g/L The level of plasma endotoxin was markedly decreased in the group A compared with group B Conclusion: Bifidobacterium bifidum agents was effective in preventing spontaneous bacterial peritonitis in patients with ascites