饮水砷暴露与肺癌发病关系的Meta分析

Dose-response relationship between arsenic exposure through drinking water and incidence of lung cancer:a meta-analysis

目的探索饮用水中砷浓度与肺癌发病率的剂量-反应关系。方法通过国内外主要数据库检索到符合分析要求的2012年以前发表的4篇关于饮用水(自来水、地表水、井水)中砷浓度与肺癌发病关系的文献进行Meta分析。结果经异质性检验,各研究结果存在异质性(P<0.10);故以随机效应模型拟合,结果显示,经线性回归拟合斜率,饮用水中砷浓度每增加1μg/L,肺癌发病风险提高0.15%。结论饮用较高砷浓度水的人群肺癌发病的风险较高。

Objective To explore the dose-response relationship between arsenic levels in drinking water and incidence of lung cancer. Methods Four papers associated with the relationships between arsenic concentration in drinking water（tap water,ground water or well water） and lung cancer risk, published before 2012, were analyzed by using an updated meta-analysis of literature. Results There was heterogeneity between four papers（P〈0.05）. Random effect model results showed that the risk of lung cancer increased 0.15% times with the concentration of arsenic in drinking water increasing 1 μg/L. Conclusion The risk of lung cancer may increase as arsenic concentration in drinking water increase.