生物膜中不同定植阶段细菌间的相互作用及模型

Interactions among bacteria of different colonization processes within biofilms and the model

牙菌斑生物膜是引发口腔龋病和牙周病的重要因素。在牙菌斑生物膜形成过程中,中晚期定植菌并非直接附着于牙面,而是依赖于识别早期定植菌表面的多糖或蛋白受体,因而早期和中晚期定植菌之间的相互作用对生物膜的形成至关重要。近年来,体外生物膜模型被广泛应用于细菌间相互作用的研究,本文就以生物膜为依托的细菌间相互作用及体外生物膜模型的应用作一综述。

Dental plaque biofilms have important functions in initiating oral caries and periodontal diseases. Given that middle and late colonizers recognize polysaccharide or protein receptors on the pioneer bacterial cell surface rather than attaching directly to the tooth surface, the interactions between early, middle, and late colonizers during biofilm formation are very important. These interactions have become the focus of research in many laboratories. Furthermore, various biofi lm models have been increasingly applied in vitro for studies on interspecies interactions. In this mini-review, interspecies interactions within dental plaque biofi lm and development of biofi lm formation models will be discussed.