滤泡样树突细胞分泌蛋白的自然免疫作用和在口腔组织中的表达

Innate immune effect and its expression level in oral tissues of follicular dendritic cells secreted protein

滤泡样树突细胞分泌蛋白(FDC-SP)是一种由滤泡样树突细胞产生的可锚定于B细胞表面的蛋白质,其基因定位于4q13富含脯氨酸的唾液多肽和半胱氨酸-X-半胱氨酸趋化因子基因簇染色体4开放阅读框7附近,既可调节抗体应答、B细胞趋化,亦可参与防御功能。FDC-SP表达于淋巴生发中心亮区,还表达于白细胞浸润的扁桃体隐窝以及脂多糖(LPS)、金黄色葡萄球菌Cowan-1株活化的白细胞中,也表达于牙龈沟内结合上皮,体现其在口腔自然免疫防御过程中的重要性。在口腔中,FDC-SP正向调节牙周膜细胞的增殖并通过表皮生长因子受体信号转导途径抑制成纤维细胞分化为矿化组织细胞,作为口腔自然免疫防御的结合上皮的特异性标志分子,其表达水平与LPS息息相关,可通过对其的定位和定量测定揭示牙周健康状况及牙周疾病的进展。

Follicular dendritic cell secretory protein（FDC-SP） is a protein generated by a follicular dendritic cell. FDCSP can bind to the surface of B cells whose gene lies on chromosome 4q13 adjacent to the clusters of proline-rich salivary peptides. Cysteine-X-Cysteine chemokine, which is adjacent to chromosome 4 open reading frame 7, not only regulates the antibody response and B cell chemotaxis but is also involved in the innate immune response. FDC-SP is expressed in the light zone of germinal-center leukocyte-infi ltrated tonsil crypts by lipopolysaccharide（LPS）, Staphylococcus aureus Cowan strain 1-activated leukocytes, or junctional epithelium in the oral cavity. FDC-SP is therefore signifi cant in oral innate immunity. In addition, FDC-SP positively affects the proliferation of periodontal ligament cells and inhibits their differentiation into the mineralized tissue cells of fibroblasts through the epidermal growth factor receptor signal transduction pathway. As a specifi c biomarker of junctional epithelium in oral innate immunity, the expression of FDCSP is closely related to LPS level. Reports suggest that the periodontal health status and progress of periodontitis can be determined by the location or quantifi cation of FDC-SP.