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肾静脉肾素测定预测肾动脉狭窄介入治疗后血压变化价值的探讨

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摘要 肾动脉狭窄(RAS)常表现为肾血管性高血压(RVH)和缺血性肾病,65岁以上老年人中的发病率不低于7%[1]。近年来经皮腔内肾血管成形及支架植入术已广泛应用于RAS的治疗[2],但并不是所有RAS患者都能从介入治疗中获益,大约70%患者术后血压改善甚至治愈[3]。为此,需要预测介入手术术后血压变化并选择可以从中获益的患者。RVH由肾素-血管紧张素-醛固酮系统(RAAS)激活引起[4],过去认为肾静脉肾素(PRA)活性测定可以作为评估介入手术后血压变化的指标[5],目前对此存有争议。本文采用临床高度怀疑RAS的患者行肾动脉造影,并测定肾静脉及下腔静脉PRA,观察动态血压,藉以评价PRA测定对预测介入治疗后血压变化有无临床意义。
出处 《浙江临床医学》 2014年第6期894-896,共3页 Zhejiang Clinical Medical Journal
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