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硫辛酸治疗早期糖尿病肾病50例观察 被引量：1

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摘要 随着人们生活水平的提高，糖尿病患病率也越来越高，糖尿病肾病（diabetic nephropathy，DN）作为糖尿病常见并发症正日益危害患者的健康，而早期DN经过积极治疗可以完全逆转，故探讨DN发病机制有助于更有效治疗。DN发病机制复杂，一般认为与遗传背景、代谢紊乱、肾血流动力学的改变、多种细胞因子以及氧化应激有关，其中氧化应激已受到高度关注。作者选择一组早期DN患者，给予硫辛酸治疗，取得了较好的疗效。报告如下。
作者 陈雄威 李唯佳
机构地区 浙江省立同德医院内分泌科
出处 《浙江临床医学》 2014年第6期938-939,共2页 Zhejiang Clinical Medical Journal
关键词 早期糖尿病肾病 积极治疗 硫辛酸 糖尿病患病率 肾血流动力学 发病机制 氧化应激 常见并发症
分类号 R587.2 [医药卫生—内分泌]
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参考文献7

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共引文献45

同被引文献24

  • 1颜新凤,冯波,徐雷,薛俊丽.α-硫辛酸对2型糖尿病大鼠肾脏显微和超微组织结构的影响[J].中国实用内科杂志,2007,27(23):1846-1848. 被引量：17
  • 2Giacco F,Brownlee M.Oxidative stress and diabetic compli-cations[J].Circ Res,2010,107(9):1058.
  • 3Vasavada N,Agarwal.Ole of oxidative stress in diabeticnephropathy[J].Adv Chronic Kidney Dis,2005,12(2):146.
  • 4Higgins JPT,Green S.Cochrance Handbook for Systematic Reviews of Interventions[J].The Cichrane Collaboration,2006,4(2):6.
  • 5Al-Mutairi N,Al-Farag S,Al-Mutairi A,et al.Comorbidities associated withpsoriasis:an experience from the Middle East[J].The Journal of der-matology,2010,37(2):146-155.
  • 6Oksala NK,Lappalainen J,Laaksonen DE,et al.Alpha-lipoic Acid modulates heat shock factor-1 expression in streptozotocin-induced diabetic rat kidney[J].Antioxid Redox Signal,2007,9(4):497-506.
  • 7Yi X,Nickeleit V,James LR,et al.Lipoic acid protects diabetic apolipoprotein E-deficient mice from nephropathy[J].J Dia-betes Complications,2011,25(3):193-201.
  • 8Yi X,Xu L,Hiller S,et al.Educed Expressionof Lipoic Acid Synthase Accelerates Diabetic Nephropathy[J].J Am Soc Nephro,2012,23(1):103-111.
  • 9Feng B,Yan XF,Xue JL,et al.The protective effects ofα-lipoic acid on kidneys in type 2 diabetic goto-kakisakirats via reducing oxidative stress[J].Int J Mol Sci,2013,14(4):6746-6756.
  • 10方文军,金杰,董艳,秦利,苏青.硫辛酸治疗Ⅳ期糖尿病肾病64例[J].中国新药与临床杂志,2008,27(11):835-838. 被引量：6

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浙江临床医学
2014年 第6期

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