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高效液相色谱法手性固定相拆分手性药物研究进展 被引量：4

Recent advances in enantio separating chiral drugs by CSP of HPLC
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摘要 高效液相色谱法(HPLC)作为最常用的药物分析方法对手性药物的拆分具有广泛的应用,而手性固定相(CSP)则是拆分效果的关键因素。介绍了近几年手性固定相在手性药物拆分中的研究进展,并展望其发展前景。 As the most common method used for drug analysis,HPLC has been widely used for enantio separating of chiral drugs,and CSP is a key factor of isolation effect. Reviewed the advances in enantio separating of chiral drugs by CSPs latest years and predict for the future developments.
作者 李雪 李优鑫 张勇
机构地区 天津市现代药物传递及功能高效化重点实验室天津大学药物科学与技术学院
出处 《应用化工》 CAS CSCD 2014年第6期1125-1127,1132,共4页 Applied Chemical Industry
基金 国家自然科学基金资助项目(21375093) 教育部高等学校博士学科专项科研基金资助(20130032120081)
关键词 手性药物 高效液相色谱 手性固定相 chiral drugs HPLC CSP
分类号 TQ460 [化学工程—制药化工] R917 [医药卫生—药物分析学]
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参考文献25

  • 1Qiu H,Liang X,Sun M,et al.Development of silica-based stationary phases for high-performance liquid chromatography[J].Analytical and Bioanalytical Chemistry,2011,399(10):3307-3322.
  • 2Xiao Y,Siu-Choon Ng,Timothy Thatt Yang Tan,et al.Recent development of cyclodextrin chiral stationary phases and their applications in chromatography[J].Journal of Chromatography A,2012,1269:52-68.
  • 3Nikolic K,IvkoviB,Beovi,et al.A validated enantiospecific method for determination and purity assay of clopridogrel[J].Chirality,2009,21(10):878-885.
  • 4沈静茹,韦慧慰,余学红,朱财延,毛康.β-环糊精硝基衍生物HPLC柱分离手性药物扑尔敏[J].中南民族大学学报（自然科学版）,2011,30(4):32-35. 被引量：4
  • 5Rao R N,Talluri M V N,Maurya P K.Separation of stereoisomers of sertraline and its related enantiomeric impurities on a dimethylatedβ-cyclodextrin stationary phase by HPLC[J].Journal of Pharmaceutical and Biomedical Analysis,2009,50(3):281-286.
  • 6Zhao J,Tan D,Chelvi S K,et al.Preparation and application of rifamycin-capped(3-(2-O-β-cyclodextrin)-2-hydroxypropoxy)-propylsilyl-appended silica particles as chiral stationary phase for high-performance liquid chromatography[J].Talanta,2010,83(1):286-290.
  • 7Chankvetadze B.Recent developments on polysaccharidebased chiral stationary phases for liquid-phase separation of enantiomers[J].Journal of Chromatography A,2012,1269:26-51.
  • 8Peng L,Jayapalan S,Chankvetadze B,et al.Reversedphase chiral HPLC and LC/MS analysis with tris(chloromethylphenylcarbamate)derivatives of cellulose and amylose as chiral stationary phases[J].Journal of Chromatography A,2010,1217(44):6942-6955.
  • 9Antonina Mskhiladze,Marina Karchkhadze,Alexandre Dadianidze,et al.Enantioseparation of chiral antimycotic drugs by HPLC with polysaccharide-based chiral columns and polar organic mobile phases with emphasis on enantiomer elution order[J].Chromatographia,2013,76:1449-1458.
  • 10Hefnawy M M,Al-Shehri M,Sultan M,et al.Enantiomeric resolution and determination of clenbuterol by HPLC technique in plasma and pharmaceutical formulations using polysaccharide chiral stationary phase and UV detection[J].Digest Journal of Nanomaterials and Biostructures,2013,8(4):1781-1790.

二级参考文献6

  • 1杨曦,沈静茹,李云.双6-氧■3-间硝基苯磺酰基-丁二酸-1,4-单酯-4■β-环糊精的合成及模拟抗坏血酸氧化酶[J].中南民族大学学报（自然科学版）,2006,25(4):28-30. 被引量：2
  • 2Chen Q C, Jeong S J, Hwang G S, et al. Enantiose lective determination of chlorpheniramine in various formulations by HPLC using carboxymethyl-β-cyclodextrin as a chiral additive [ J ]. Archives of Pharmacal Research, 2008,31 (4) :523-529.
  • 3Haginaka J, Kagawa C. Uniformly sized molecularly imprinted polymer for d-chlorpheniramine evaluation of retention and molecular recognition properties in an aqueous mobile phase [ J ]. Journal of Chromatography A ,2002,948:77-84.
  • 4Fried K M, Young A E, Yasuda S U, et al. The enantioselective determination of chlorpheniramine and its major metabolites in human plasma using chiral chromatography on a jS-cyclodextrin chiral stationary phase and mass spectrometric detection [ J ]. Journal of Pharmaceutical and Biomedical Analysis, 2002, 27 : 479-488.
  • 5Wang Huaisong, Xu Dan, Jiang Ping, et al. Novel restricted access chiral stationary phase synthesized via atom transfer radical polymerization for the analysis of chiral drugs in biological matrices [ J]. Analyst, 2010, 135 : 1785-1792.
  • 6Wind M, Hoffmann P, Wagner H, et al. Chiral capillary electrophoresis as predictor for separation of drug enantiomers in continuous flow zone electrophoresis [ J ]. Journal of Chromatography A ,2000,895:51-65.

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应用化工
2014年 第6期

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