特异性IgM抗体检测在新生儿先天性梅毒诊断中的临床意义

Specific IgM antibody detection in the diagnosis of neonatal congenital syphilis

目的:探讨特异性IgM抗体检测对诊断新生儿先天性梅毒的临床意义。方法:选择先天性梅毒新生儿100例作为研究对象,分别应用特异性IgM法及常规ELISA法进行检测,对两种不同检测方法下的阳性检出率进行综合对比与分析。结果:特异性IgM法检出阳性率为97.00%,ELISA检测方法下的检出阳性率为75.00%,IgM法下的检出阳性率明显高于ELISA法阳性检出率,差异有统计学意义(P<0.05)。结论:特异性IgM抗体检测新生儿先天性梅毒灵敏度高,可作为本病基础性检测方法。

Objective To investigate the clinical significance of detection of specific IgM antibody in the diagnosis of neonatal congenital syphilis.Methods 100 cases of neonatal congenital syphilis as the research object,using specific IgM method and the conventional ELISA method for detection of two different detection methods,the positive rate of comprehensive comparison and analysis.Results The specific IgM positive rate was 97%,the positive rate of ELISA detection methods was 75%,the positive rate of IgM detection method was significantly higher than that in ELISA positive rate,the difference was statistically significant（P 〈 0.05）.Conclusion The detection of specific IgM antibody of newborn congenital syphilis and high sensitivity, can be used as the basis of detecting method of the disease.