胃间质瘤临床病理因素与预后分析

Analysis of Clinicopathological Factors and Prognosis of Gastric Stromal Tumor

目的探讨胃间质瘤（gasric stromal tumor,GST）的临床病理因素和预后。方法回顾性分析解放军总医院2005年7月—2013年9月手术治疗的有完整记录103例GST的临床资料。结果 103例随访1～84个月,平均27个月,总体1、3、5年生存率分别为95%、89%、80%,中位生存期68个月。单因素分析显示肿瘤部位、是否破裂、Fletcher风险分级、Ki-67指数、是否R0切除和术后是否应用伊马替尼与GST预后相关（P〈0.05）;多因素分析显示是否R0切除是影响GST预后的独立危险因素（P〈0.05）。结论 GST预后与肿瘤生长部位等多种因素相关,能否R0切除是影响其预后的重要因素。

Objective To investigate clinicopathological factors and prognosis of gastric stromal tumors（ GST）.Methods Clinical data of 103 GST patients undergoing surgery during July 2005 and September 2013 in General Hospital of PLA was retrospectively analyzed. Results The 103 patients were followed up for 1- 84 months with an average time of 27 months. The total survival rates of one year,three years and five years were 95%,89% and 80% respectively with a median survival of 68 months. Univariate analysis showed that the prognosis was related to the tumor positions,whether there was rupture or not,Flecture risk classifications,Ki-67 indexes,whether there was R0resection and application of Imatinib after operation or not（ P〈0. 05）; multivariate analysis showed that R0resection was an independent risk factor of prognosis（ P〈 0. 05）. Conclusion The prognosis of gastric stromal tumor is related to many clinicopathological factors such as tumor position,and R0is the most important influence factor of the prognosis.