NT-proBNP对心源性胸腔积液诊断价值的meta分析

A Meta Analysis of NT-proBNP Value in Diagnosis of Cardiogenic Pleural Effusion

目的探讨氨基末端B型利钠肽前体(N-terminal-pro-B-type natriuretic peptide,NT-proBNP)在诊断心源性胸腔积液中的临床价值。方法检索Pubmed、Embase、中国知网、万方、维普等数据库,收集利用NT-proBNP诊断心源性胸腔积液文献并提取数据进行meta分析。结果共有15篇文献1892例研究对象纳入本次meta分析,分析结果显示NT-proBNP对心源性胸腔积液的综合诊断价值分别为:敏感度为0.91(95%CI:0.89,0.93),特异度为0.89(95%CI:0.87,0.90),阳性似然比为10.05(95%CI:6.34,15.94),阴性似然比为0.11(95%CI:0.08,0.17),诊断比值比为106.00(95%CI:50.89,220.79)。综合受试者工作特征曲线下面积为0.97。结论 NT-proBNP对心源性胸腔积液具有重要的诊断价值。

Objective To explore the clinical value of N-terminal-pro-B-type natriuretic peptide（ NT-proBNP）in diagnosis of cardiogenic pleural effusion. Methods Date about NT-proBNP in diagnosis of cardiogenic pleural effusion was retrieved from Pubmed,Embase,CNKI,WanFang Database and VIP Database,and the selected data underwent meta analysis. Results Fifteen documents containing 1892 cases were included in the Meta analysis. The results showed that NT-proBNP value in comprehensive diagnosis of cardiogenic pleural effusion were 0. 91 of sensitivity（ 95% CI：0. 89,0. 93）,0. 89 of specificity（ 95% CI： 0. 87,0. 90）,10. 05 of positive likelihood ratio（ 95% CI： 6. 34,15. 94）,0. 11 of negative likelihood ratio（ 95% CI： 0. 08,0. 17） and 106. 00 of diagnostic odds ratio（ 95% CI： 50. 89,220. 79）.The area under curve of synthetic receiver operator characteristic curve was 0. 97. Conclusion NT-proBNP plays a valuable role in diagnosis of cardiogenic pleural effusion.