不同方法治疗海军部队人员功能性消化不良临床分析

Clinical Analysis of Different Methods in Treatment of Functional Dyspepsia in Naval Personnel

目的探讨不同方法在治疗海军部队人员功能性消化不良(functional dyspepsia,FD)的疗效及临床意义。方法我院2007年6月—2011年12月筛选临床诊断FD 3084例,采用分层抽样法随机选取250例,分为5组,每组50例。A组给予常规抑酸联合促胃肠动力治疗,B组给予单纯抗抑郁焦虑治疗,C组根据辨证分型给予中药治疗,D组采用起搏器治疗,E组给予安慰剂治疗。比较5组治疗前后临床症状评分改善情况及各临床因素间的交互作用。结果 A^D组治疗1、2、4周后临床症状评分均较治疗前降低,且A、C组改善程度明显优于其余3组,A组治疗效果时间间隔短于其余4组。析因试验方差分析显示不同治疗方法、不同治疗时间因素间均存在显著性差异(F=184.970、167.597,P=0.000);同时治疗方法 -治疗时间因素间存在显著性的交互效应(F=10.510,P=0.000)。结论不同治疗方法对海军部队人员FD均有不同程度临床疗效,但常规西药治疗临床症状缓解时间间隔及总体治疗效果优于其他治疗方法。

Objective To explore the curative effects and clinical significance of different methods in treatment of functional dyspepsia（ FD） in naval personnel. Methods A total of 250 patients were randomly selected from screening and clinical diagnosing 3084 FD patients during June 2007 and December 2011 by stratified sampling method,and were divided into 5 groups（ each n = 50）. Group A was treated with conventional acid-suppressing combined with promotion of gastrointestinal motility; group B was given a simple antidepressant and antianxiety treatments; group C was treated with traditional Chinese medicine therapy according to the zheng differentiation-classification; group D was given a pacemaker; group E received a placebo treatment. Changes of quantifying scores for clinical symptoms and interaction of clinical factors before and after treatment in the 5 groups were compared. Results The quantifying scores for clinical symptoms after treatment for 1 week,2 weeks and 4 weeks in group A,B,C and D were decreased,compared with those before treatment,and the improvement in group A and C was better than those in group B,D and E,and the interval of treatment effectiveness in group A was shorter than those in other 4 groups. Factorial experimental variance analysis showed that there were significant differences with different treatment methods in different times（ F = 184. 9701,167. 597,P = 0. 000）; there was a significant interaction between treatment methods and time（ F = 10. 510,P =0. 000）. Conclusion Different methods in treatment of FD in naval forces may achieve different levels of clinical efficacy,while interval of symptomatic relief and total treatment effectiveness by conventional Western medicine may be better than that by the other methods.