白细胞介素-8与脑缺血

Interleukin-8 and cerebral ischemia

免疫炎症是缺血性脑损伤的主要病理生理学机制之一,其中趋化因子及其受体广泛参与缺血性脑损伤的发生和发展过程.白细胞介素-8（interleukin-8,IL-8）及其受体参与激活和趋化中性粒细胞进入脑组织,可进一步加重脑缺血再灌注损伤.目前,针对IL-8的治疗药物主要是CXC趋化因子受体2拮抗剂,包括单个趋化因子和广谱趋化因子拮抗剂.文章对IL-8在缺血性脑损伤中的病理学机制和靶向治疗研究进展进行了综述.

Immuno-inflammation is one of the main pathophysiological mechanisms of ischemic brain injury,of which chemokines and its receptors widely participate in the occurrence and development processes of ischemic brain injury.Interleukin-8 （IL-8） and its receptors participate in the activation and chemotaxis of neutrophils into brain tissue,and may further aggravate cerebral ischemia-reperfusion injury.At present,therapeutic drugs for IL-8 are mainly CXC chemokine receptor 2 antagonists,including narrow and broad-spectrum chemokine antagonists.This article reviews the advances in research on the pathological mechanism and targeting treatment of IL-8 in ischemic brain injury.