微流控法制备新型微颗粒功能材料研究新进展

Recent progress of microfluidic fabrication of novel functional microparticles

微颗粒功能材料在药物传送与控制释放、活性物质封装保护、微反应以及微分离等方面具有极其广泛的应用。相对于传统的微颗粒制备方法,近年来发展起来的微流控技术为可控制备具有不同结构和功能的单分散微颗粒功能材料提供了一个更为优越的技术平台。综述了微流控法制备新型微颗粒功能材料的研究新进展,重点介绍了利用微流控法可控制备具有良好单分散性的球形、非球形、中空型、核-壳型、孔-壳型以及多腔室型功能微颗粒的研究现状。

Functional microparticles are widely used in various fields, such as delivery and controlled release of drugs, encapsulation and protection of active materials, micro-reactions and micro-separations. Compared with traditional techniques for preparing microparticles, microfluidic technique provides an advanced platform for fabrication of monodisperse functional microparticles with well-controlled structures and functions. This review summarizes recent progress of microfluidic fabrication of novel functional microparticles. Emphases are focused on controllable fabrication of monodisperse spherical, non-spherical, hollow, core-shell, hole-shell, and multi-compartment microparticles by microfluidic techniques.