甲状腺癌危险因素病例对照研究

Risk factors of thyroid cancer: a case-control study

目的了解甲状腺癌发病的相关危险因素,为甲状腺癌的防治提供科学依据。方法采用1∶1配对病例对照研究,选择2008—2009年辽宁省大连市新发甲状腺癌患者200例及同期住院符合配对条件的非肿瘤及内分泌系统疾病的患者200例为对照组,使用统一设计的调查表进行问卷调查。结果单因素分析结果显示,口味重、调查前10年食用较多海洋动物性食品、海菜类及腌制食品、经常感到有压力、爱生闷气、遇事不愿与人倾诉、处事态度偏于悲观、婚姻生活不和谐及与人相处不融洽为甲状腺癌的危险因素;多因素条件logistic回归分析结果显示,调查前10年食用较多海洋动物性食品（OR=9.484,95%CI=3.868～23.256）、海菜类（OR=1.933,95%CI=1.209～3.092）摄入过多、爱生闷气（OR=3.804,95%CI=1.482～9.765）以及与人相处不融洽（OR=2.460,95%CI=1.149～5.266）为甲状腺癌的危险因素。结论甲状腺癌的发生与碘摄入量以及社会心理环境等因素密切相关。

Objective To investigate the risk factors of thyroid cancer and to provide scientific basis for prevention of thyroid cancer. Methods A 1：1 matched case-control study was conducted. Two hundreds cases were chosen from inpatients with thyroid cancer diagnosed in Dalian city from 2008 - 2009 and the controls were chosen from inpatients without cancer and endocrine systemic diseases and hospitalized in the same hospital and the same period as the cases. A face- to-face survey was conducted with a self-desinged questionnaire. Results Univariate conditional analyses showed that liking salty food ten years ago, more consumption of seafood, seaweed, and pickled foods, with stress frequently, with pessimistic attitude, without harmonious marriage, and without good relationship with others were risk factors for thyroid cancer. The results of multivariate condition logistic regression analyses showed that eating too much seafood（ odds ratio [ OR] = 9. 484,95% confidence interval [ 95% CI] = 3.868 - 23. 256 ） and kelp ten years ago （ OR = 1. 933,95% CI = 1. 209 - 3. 092 ）, being sulking easily （ OR = 3. 804,95% CI = 1. 482 - 9. 765 ）, without good relationship with others （ OR = 2, 460,95% CI = 1. 149 - 5.266） were the risk factors of the thyroid cancer. Conclusion Thyroid cancer incidence has close relationship with iodine intake and social psychological factors.