脂代谢异常与子宫内膜腺癌发生的相关因素研究

Lipid metabolism disorders as risk factors for endometrial adenocarcinoma

目的通过分析子宫内膜腺癌(endometrial adenocarcinoma,EMA)患者的代谢指标,探讨脂代谢异常与子宫内膜腺癌发生的关系。方法收集68例子宫内膜腺癌患者(内膜癌组)和同期61例正常子宫内膜健康体检者(对照组)的临床资料,检测两组的血脂代谢指标、空腹血糖(fasting plasma glucose,FPG)、空腹血清胰岛素(fasting serum insulin,FINS)及稳态模型评估的胰岛素抵抗(homeostasis model assessment for insulin resistance,HOMA-IR)水平的差异。采用非条件logistic回归模型分析发生子宫内膜腺癌的危险因素,并探讨其与子宫内膜腺癌临床病理特征的关系。结果内膜癌组的各项血脂指标、FINS和HOMA-IR均高于正常对照组(P均<0.05);甘油三酯(triglycerides,TG)、FINS、HOMA-IR与子宫内膜腺癌的临床病理特征无明显相关,差异均无统计学意义(P均>0.05)。结论体质指数、腰围、TG、FINS和HOMA-IR与EMA的发生密切相关。FINS、TG升高和存在HOMA-IR可作为子宫内膜腺癌的预测因子。

Objective To explore possible relationships between lipid metabolism disorders and the occurrence of endometrial adenocarcinoma （EMA）. Methods A total of 68 patients with EMA and 61 control women were compared in terms of lipid metabolism indicators,fasting plasma glucose （FPG）,fasting serum insulin （FINS）and homeostasis model assessment for insulin resistance（HOMA-IR）.Pooled odds ratios were estimated using non-conditional logistic regression to identify factors associated with risk of EMA and with clinicopathological features of the disease. Results The lipid indexes,FINS and HOMA-IR differed significantly between patients with EMA and controls （P〈0.05）.However,triglyceride levels,FINS,and HOMA-IR were not significantly associated with clinicopathological features of EMA （P〉0.05）. Conclusions EMA occurrence was associated with elevated body mass index, triglycerides,FINS,waist circumference,HOMA-IR.Elevated FINS,triglycerides and HOMA-IR may be useful as predictors of endometrial carcinoma.