视黄醇结合蛋白在肾脏疾病中的诊断意义

Serum retinol binding protein levels in renal diseases

目的探讨视黄醇结合蛋白(RBP)检测在肾脏疾病中的诊断意义。方法检测167例肾病患者和57例健康体检者的血清RBP、尿素氮、肌酐、血白蛋白、甲状旁腺素(PTH)、β_2微球蛋白,计算肌酐清除率,探讨RBP与传统肾功能指标的关系以及其在诊断肾脏疾病中的临床意义。结果随肾小球滤过率(GFR)降低,尿素氮、肌酐、RBP、PTH、β_2微球蛋白水平逐渐增高,当GFR<60ml/(mllq·1.73m^2)时,肌酐、RBP、β_2微球蛋白水平较对照组明显增高(P<005);RBP与肌酐、尿素氮、PTH、β_2微球蛋白呈正相关(P<0.05),与内生肌酐清除率呈负相关(P<0.05)。随着肾功能逐渐下降,血RBP检测阳性率逐渐增高。结论 RBP是可作为早期诊断肾脏疾病的重要指标。

Objective To investigate serum retinol binding protein （RBP） levels in renal diseases. Methods Serum RBP, creatinine,urea,albumin, parathyroid hormone（PTH）,β2 microglobulin were determined in 167 patients with renal disease. Results The serum creatinine, urea, PTH, RBP and β2 microglobulin levels were increased with the decreasing glomerular filtration rate （GFR）. When GFR was lower than 60 ml/ （min＆#183;1.73m2）, there were significant differences in serum RBP, creatinine and β2 mi-croglobulin levels between patients and controls. RBP levels were positively correlated with creatinine, urea, PTH and β2 mi-croglobulin（P〈0.05）;negatively correlated with endogenous creatinine clearance rate （Ccr） （P〈0.05）. Conclusion Serum RBP levels are increased in renal diseases, which may indicate the degree of severity of renal impairment in patients with nephropathy.