脑出血患者血浆凝溶胶蛋白早期检测的临床价值

Early determination of plasma gelsolin for prognosis of patients with intracerebral hemorrhage

目的探讨早期检测脑出血患者血浆凝溶胶蛋白浓度与脑出血长期预后的关系。方法选取脑出血患者和健康体检者各126例,采用ELISA法检测血浆凝溶胶蛋白浓度,分析其对脑出血患者1年死亡和预后不良(mRS评分>2分)的预测价值。结果脑出血患者血浆凝溶胶蛋白浓度较健康体检者显著降低,与NIHSS评分呈显著负相关,是脑出血患者1年死亡和预后不良的独立危险因素,可预测脑出血患者1年死亡和预后不良。结论脑出血患者血浆凝溶胶蛋白浓度显著降低,该指标可预测脑出血患者长期预后。

Objective To evaluate the determination of plasma gelsolin levels in long- term prognosis of patients with in-tracerebral hemorrhage （ICH）. Methods Plasma gelsolin levels were measured with ELISA method in 126 ICH patients and 126 healthy subjects. Predictive value of plasma gelsolin level for 1- year mortality and unfavorable outcome （mRS score〉2） of pa-tients was analyzed. Results Compared with healthy subjects, plasma gelsolin levels in patients with ICH were significantly de-creased. Plasma gelsolin was negatively associated with National Institute of Health Stroke Scale （NIHSS） score;and it was an in-dependent risk factor of 1- year mortality and unfavorable outcome of ICH patients. Conclusion Plasma gelsolin level in patients with ICH is decreased, and it can predict the long- term outcome of ICH patients.