老年人急性髓系白血病的治疗
摘要
急性髓系白血病(AML)是一组异质性恶性血液病,其主要特点为白血病细胞的生长失控及分化受阻。AML好发于老年人,发病年龄主要为65~70岁。随着年龄的增长,AML的发生可能与不良的细胞遗传学异常,体能状态(PS)下降及伴发其他疾病相关。老年AML患者的预后不佳,可能是由于伴有不良的染色体核型异常,对化疗药物产生抵抗或耐药。
出处
《实用老年医学》
CAS
2014年第6期460-464,共5页
Practical Geriatrics
参考文献25
-
1Lowenberg B, Downing JR, Burnett A. Acute myeloid leukemia [ J ] N Engl J Med, 1999, 341 ( 14): 1051-1062.
-
2Burnett A, Wetzler M, Lowenberg B. Therapeutic advances in acute myeloid leukemia[ J ]. J Clin Oncol, 2011, 29(5) :487-494.
-
3Estey E. AML in older patients: are we making progress? [ J]. Best Pract Res Clin Haematol, 2009, 22 (4) : 529-536.
-
4Grimwade D, Walker H, Oliver F, et al. The importance of diagnostic cytogenetics on outcome in AML: a- nalysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties [ J ]. Blood, 1998, 92 (7) : 2322-2333.
-
5Frohling S, Schlenk RF, Kayser S, et al. Cytogenetics and age are major determinants of outcome in intensively treated acute myeloid leu-kemia patients older than 60 years: results from AMLSG trial AML HD98-B [ J ]. Blood, 2006, 108 (80) : 3280-3288.
-
6Kantarjian HM, Thomas XG, Dmoszynska A, et al. Muhicenter, randomized, open-label, phase I trim of decitabine versus patient choice, with physician advice, of ei- ther supportive care or low-dose cyt- arabine for the treatment of older pa- tients with newly diagnosed acute myeloid leukemia[ J]. J Clin Oncol, 2012, 30(21 ) :2670-2677.
-
7Roboz GJ, Wissa U, Ritchie EK, et al. Are low-intensity induction strate- gies better for older patients with acute myeloid leukemia? [ J]. Leuk Res, 2012, 36(4):407-412.
-
8Takahashi K, Garcia-Manero G, Jorge E, et al. Fludarabine and cyt- arabine based induction therapy is associated with high response rate and durable remission with low treat- ment related mortality in elderly pa- tients with core-binding factor AML (CBF-AML) [ C ]. Blood, 2013, 122 (21) :3945.
-
9Minauchi K, Obara M, Ara T, et al. Aclarubicin, Low-dose cytarabine combined with G-CSF ( CAG ) regimen for patients previously treated or ineligible for intensive chemotherapy with acute myeloid leu- kemia and myelodysplastic syndrom: a single center experience [ C ]. Blood, 2013,122 ( 21 ) : 2697.
-
10Visani G, Ferrara F, Di Raimondo F, et al. Low-dose lenalidomide plus cytarabine induce complete remission that can be predicted by genetic pro- filing in elderly acute myeloid leukemia patients. [ J ]. Leukemia, 2014, 28(4) :967-970.
-
1英国发现癌细胞生长失控的秘密[J].中国科技产业,1997(4):33-33.
-
2于景翠,孙开来.人类肿瘤中17号染色体杂合性缺失的研究进展[J].国外医学(遗传学分册),2004,27(2):97-101.
-
3田丽军,徐兵河.Cyclin D1与乳腺癌相关性研究进展[J].国外医学(肿瘤学分册),2004,31(5):368-371. 被引量:1
-
4徐成,郎锦义.EGFR基因突变与非小细胞肺癌(NSCLC)的靶向治疗[J].四川肿瘤防治,2007,20(4):305-308. 被引量:1
-
5王剑.肿瘤基因治疗的新技术[J].国外医学(肿瘤学分册),1994,21(6):339-344. 被引量:1
-
6张畅,宁勇.MicroRNA与恶性肿瘤[J].中外医学研究,2012,10(1):159-161. 被引量:6
-
7刘腾飞,甘润良,冬毕华.胃癌染色体杂合性丢失研究进展[J].国外医学(遗传学分册),2002,25(4):228-232.
-
8凌云峰,冯震博,何如昆,吕自力.转化生长因子β1及其Ⅰ、Ⅱ型受体在肝细胞癌中的表达[J].临床肝胆病杂志,2005,21(1):35-37. 被引量:4
-
9范建华,赵建阳,成国祥.EGFR单抗与肿瘤治疗进展[J].中国肿瘤生物治疗杂志,2003,10(3):221-222. 被引量:3
-
10王晓瑜,甘润良.胃癌相关基因的功能和作用[J].医学综述,2012,18(6):854-858. 被引量:4