摘要
目的观察131I治疗老年分化型甲状腺癌(differentiated thyroid carcinoma,DTC)肺转移的疗效及不良反应。方法对31例老年DTC肺转移患者进行131I治疗,并采用胸部CT、131I显像及Tg变化综合判断疗效,并对可能影响131I治疗DTC肺转移疗效的主要因素进行分析。结果131I治疗的有效率为67.7%(21/31);有无合并其他脏器远处转移(P=0.0059)及肺病灶类型(P=0.0271)为131I治疗DTC肺转移疗效的主要影响因素;随访期内未出现由131I治疗引起的肺纤维化、造血系统抑制、慢性涎腺炎和继发肿瘤。结论131I治疗老年DTC肺转移有较好的疗效,不良反应低。
Objective To determine the therapeutic effect and safety of ^131I for lung metastases from differentiated thyroid cancer （DTC） in elder patients. Method Thirty one elder patients with lung metastases from differentiated thyroid cancer received ^131I therapy. The therapeutic effect was assessed comprehensively by detection of chest computed tomography （CT）, whole body scan by ^131I and thyroglobulin （Tg）. Meanwhile, the main factors that influence ^131I thera- peutic effect and safety were analyzed. Result In 31 cases with lung metastases from DTC, the response rate is 67.7% （21/31）. Significant statistical differences were found in the incidence of other distant metastases （P = 0. 0059） and the types of lung lesions in the group （P = 0. 0271 ）. No pulmonary fibrosis, hematopoietie system inhibition, chronic sialadenitis and secondary tumors caused by ^131I therapy were found in the follow-up period. Conclusion ^131I therapy is effective and safe for lung metastases from DTC in elder patients.
出处
《癌症进展》
2014年第3期264-267,共4页
Oncology Progress
