人体肺部组织复阻抗特性研究

Study on Complex Impedance Properties of Human Lung Tissue

为研究人体正常肺组织和肺癌组织复阻抗及特征参数随离体时间的变化规律,并建立肺部复阻抗实虚部对照图,为基础医学和临床诊断提供理论依据和数据参考,并为电阻抗断层成像技术(EIT)研究提供先验信息。本实验将手术切下的人体正常肺组织和肺癌组织放入测试箱中,控制测试箱的温度和湿度,控制并保持离体时间分别为30、60、80min,采用Agilent 4294A阻抗分析仪在频率为1 000Hz^30MHz范围内对人体正常肺组织和肺癌组织复阻抗进行测量。实验结果显示,在所测量的范围及对应的离体时间内,随离体时间延长,正常肺组织和肺癌组织的复阻抗均发生显著变化,但正常肺组织的阻抗值大于肺癌组织。该变化与细胞外液、细胞内液、细胞膜的变化相关。

In order to study the variation of complex impedance and characteristic parameters on human normal and tumor lung tissue during the extracorporeal time, we established a real part-imaginary part chart of complex imped- ance on lung tissue which provided the basic theory and the reference data for research on elementary medicine and clinical diagnosis of lung cancer and meanwhile provided prior information for electrical impedance tomography （EIT） research. In the experiment carried out in our laboratory, when operation was finished, we kept the lung cancer tis- sue and normal tissue neatly separated into the cylindrical testing cavities and kept the temperature and humidity at expected values. Then the measurements of complex impedance property are performed at frequency from 1 000 Hz to 30 MHz using 4294A impedance analyzer of Aglient Company. With time changing, the results showed that there was a significant change occurring on the complex impedance of human normal and tumor lung tissue. However, the impedance of normal lung tissue is greater than that of tumor lung tissue. We consider that this change should be re- lated to the change in extracellular fluid, intracellular fluid and cell membrane.