炎症小体及其在烧伤早期免疫炎症反应中的作用

Inflammasome and its role in immunological and inflammatory response at early stage of burns

炎症小体是由多种蛋白组成的复合体，可以激活半胱氨酸天冬氨酸蛋白酶1（caspase-1），活化的caspase-1进一步诱导促炎细胞因子IL-1β和IL—18的成熟和释放，促进细胞炎性坏死（pyroptosis）^[1]。

Inflammasomes are large muhi-protein complexes that serve as a platform for caspase-1 activation,and this process induces subsequent maturation and secretion of the proinflammatory cytokines IL-1β and IL-18,as well as pyroptosis.As an important component of the innate immune system,early activation of inflammasomes in a variety of immune cell subsets can mediate inflammatory response and immunological conditions after burn injury.Here,we review the current knowledge of inflammasomes and its role in immunological and inflammatory response at the early stage of burn injury.