六味地黄方对高脂血症大鼠血浆ET、TXA_2、PGI_2水平及动脉内皮保护的影响

Effects of Liuweidihuang Formula(LWDHF)on ET,TXA_2,PGI_2 and protecting the endotheliocytes in the blood plasma of rats with hyperlipidemia

目的:研究六味地黄方对高脂血症大鼠血浆ET、TXA2、PGI2水平及动脉血管内皮保护的影响。方法:通过高脂饮食建立高脂血症大鼠模型,观察大鼠外周循环内皮细胞(CEC)、主动脉病理学、内皮素(ET)、前列腺素I2(PGI2)、血栓素A2(TXA2)的变化。结果:六味地黄方能减少高脂血症大鼠外周CEC及主动脉内皮细胞损伤;降低高脂大鼠血清ET、血浆TXA2,升高血浆PGI2水平。结论:六味地黄方对高脂血症大鼠内皮细胞具有保护作用,其作用机制可能与改善内皮细胞分泌功能有关。

AIM： To observe the effects of Liuweidihuang Formula （LWDHF） on ET,TXA2, PGI2 and protecting the endotheliocytes in the blood plasma of rats with hyperlipidemia. METHODS： The hyperlipidemia rat model was established by feeding high cholesterol diet. Circulating endothelial cells （CEC） in peripheral blood and the pathological change of aortas were detected. Meanwhile the levels of plasma Endothelin （ET） , prostaglandin I2 （PGI2）, thromboxane A2 （TXA2） were measured. RESULTS： LWDHF could decrease CEC in peripheral blood and the injury of aortic endothelial cells in hyperlipidemia rats, and the levels of plasma ET, TXA2 were decreased, the level of PGI2 was increased. CONCLUSION. LWDHF might protect vascular endothelial cells of hyperlipidemia rat. The mechanism may relate to improve the secretion function of endothelial cell.