摘要
RNA干扰(RNAi)技术因其高效、特异性强等特点被广泛应用于肿瘤、病毒感染性及代谢性疾病的临床治疗。无创示踪RNAi相关分子在体内的递送过程及监测RNAi的疗效对提高RNAi的效率、促进该技术在临床中的应用具有重要意义。分子成像技术能够使活体内细胞和分子水平的生物学过程可视化,具有无创、动态、实时、定量、高特异性、高灵敏度等优点,在监测RNAi相关分子在体内的生物学过程、评估RNAi的治疗效果、加快RNAi技术的临床转化等方面有着广阔的应用前景。笔者就分子成像技术监测RNAi递送过程和评估RNAi治疗效果的研究进展进行综述。
Due to its effectiveness and specificity, RNA interference (RNAi) technology is widely used in the treatment of tumor, viral infectious and metabolic diseases. Noninvasively tracing the delivery of therapeutic RNA molecules in vivo and evaluating the therapeutic effects are important to promote the clinical application of RNAi technology. Molecular imaging allows noninvasive visualization of biological processes at the cellular and molecular level in vivo. It can be used to monitor the biodistribution of therapeutic RNA molecules and to assess the effects of the RNAi. This article reviews the advance of molecular imaging in monitoring the delivery of RNAi molecules and evaluating the therapeutic effects of RNAi.
出处
《中华核医学与分子影像杂志》
CSCD
北大核心
2014年第3期250-253,共4页
Chinese Journal of Nuclear Medicine and Molecular Imaging
基金
广东省自然科学基金(S2012040006593)
广东省产业技术研究与开发资金计划(20128050300026)