脑钠肽前体与急性脑梗死危险因素的相关研究

Study on correlation between pro-brain natriuretic peptide and risk factors of acute cerebral ischemia

目的:探讨脑钠肽前体(pro-BNP)水平与急性脑梗死危险因素的关系。方法:检测并比较66名正常健康人与125例急性脑梗死患者发病后24 h内pro-BNP和C反应蛋白(CRP)水平。采用Pearson相关分析和多因素逐步回归分析pro-BNP水平与急性脑梗死常见危险因素的相关性。结果:与正常对照组相比,脑梗死组患者血pro-BNP和CRP水平显著升高[(48.72±13.44)ng/L比(267.03±131.83)ng/L,(4.14±5.27)mg/L比(30.96±24.53)mg/L,均P<0.01]。pro-BNP水平与脑梗死常见危险因素相关(P<0.01)。多因素逐步回归分析显示,pro-BNP水平随收缩压及CRP的增加而增加(偏回归系数分别为5.291和1.052,均P<0.01)。结论:pro-BNP水平与急性脑梗死患病显著相关,CRP和收缩压是影响pro-BNP水平的独立因素。

Objective To investigate whether the pro-brain natriuretic peptide （pro-BNP） might be associated withacute cerebral ischemia and cerebrovascular risk factors. Methods pro-BNP and C-reactive protein （CRP） level wereanalyzed and compaired in 66 healthy subjects and 125 patients with acute cerebral ischemia within 24 h after onset. Thecorrelation between the value of pro-BNP and the common risk factors of acute cerebral infarction was analyzed by Pearsoncorrelation analysis and multiple stepwise regression analysis. Results Compared with normal control group, pro-BNP andCRP in stroke group were significantly higher [（48.72±13.44） ng/L vs （267.03±131.83） ng/L, （4.14±5.27） mg/L vs（30.96±24.53） mg/L, all P〈0.01], and pro-BNP level was correlated with stroke risk factors （P〈0.01）. Multiple stepwiseregression analysis showed that the level of pro-BNP increased with the increase of systolic blood pressure and CRP（partial regression coefficients were 5.291 and 1.052 respectively, all P〈0.01）. Conclusions pro-BNP level wassignificantly associated with acute cerebral ischemia, CRP and systolic blood pressure were the main independent factorsthat might influence pro-BNP level.