急性脑出血患者MMP-9表达的变化及依达拉奉干预效应的临床研究

MMP-9 changes after acute cerebral hemorrhage and intervention study with edaravone injection

目的观察急性脑出血患者基质金属蛋白酶-9(MMP-9)的表达及依达拉奉干预效应的临床疗效。方法 80例急性脑出血患者随机分为治疗组和对照组各40例。对照组给予常规治疗,治疗组在对照组治疗基础上加用依达拉奉,并在治疗后24h内和14d进行神经功能缺损评分及血浆MMP-9水平测定。结果治疗组神经功能缺损评分、血浆MMP-9水平较对照组降低(P<0.05、P<0.01)。结论依达拉奉可改善急性脑出血患者神经功能,可能与降低MMP-9水平有关。

Objective To observe the clinical efficacy of edaravone for acute cerebral hemorrhage and its impact on serum content of MMP-9.Methods A total of 80 patients were enrolled：40（control group） were randomly assigned to receive routine therapy alone, and 40 （trial group） to receive routine therapy plus edaravone.The nerve function neurological deficst, serum content of MMP-9 were compared 14d before and after treatment.Results In the trial group as compared with the control group, the nerve function deficiency scores were obviously lower （P〈0.05）, and serum content of MDA was significantly lower （P〈0.05）.Conclusion Edaravone can obviously improve the nerve function of patients with acute cerebral hemorrhage, this may be attributed to the low content of MMP-9.