急性脑梗死患者血清巨噬细胞移动抑制因子水平与病情程度相关性研究

Serum levels of macrophage migration inhibitory factor in patients with acute cerebral infarction and their correlation with disease severity

目的测定急性脑梗死患者巨噬细胞移动抑制因子(MIF)水平,分析MIF与脑梗死病情程度之间的相关性。方法选取急性脑梗死患者60例和正常对照组19例。采用双抗体夹心ELISA法检测血清MIF水平。同时检查、记录患者的入院和出院NIHSS评分,判断MIF与临床资料之间的相关性。结果与正常对照组比较,脑梗死组血清MIF水平明显降低,且轻、中、重度脑梗死组血清MIF水平均低于正常对照组。脑梗死患者血清MIF与NIHSS评分之间未发现明显相关关系;但随着脑梗死程度的加重,血清MIF水平有进一步降低的趋势。结论急性脑梗死患者血清MIF水平明显降低,在一定程度上反映了病情的严重程度,进一步证实炎症机制参与了脑梗死的病理过程。

Objective To detect the serum macrophage migration inhibitory factor （ MIF） level in patients with acute cerebral infarction and correlation with the severity of neurological deficiency .Methods 60 patients with acute cerebral infarction and 19 healthy normal control were selected .Serum MIF levels were detected using a double antibody sandwich ELISA .Meanwhile , the patient＇s admission and discharge NIHSS scores were recorded .Correlation was detected between MIF levels and NIHSS scores .Results The serum MIF decreased significantly in the cerebral infarction group compared to normal control group .Serum MIF levels in mild , medium, severe infarction groups were all significantly lower than that in the normal control group .In cerebral infarction group , no significant correlation was found between serum MIF levels and NIHSS scores;but the tendency was found in MIF level to decrease progressively with the severity of cerebral infarction .Conclusion The serum MIF decrease significantly in patients with acute cerebral infarction.MIF involves in the pathophysiology of cerebral infarction , the MIF level can reflect the severity of cerebral infarction to some extent .