血清检测胱氨酸蛋白酶抑制剂C在妊娠期高血压疾病孕妇中的临床价值

Clinical Value of Serum Cystatin-C Detection in Hypertensive Disorder Complicating Pregnancy

目的探讨血清胱氨酸蛋白酶抑制剂C(Cys-C)检测对妊娠期高血压疾病患者的诊断价值。方法2012年2月-2013年3月选取100例妊娠期高血压疾病患者为研究对象,按照病情严重程度分为轻度组、中度组和重度组,另选取同期收治的健康孕妇40例为对照组,比较4组患者血清Cys-C、尿素氮(BUN)、肌酐水平及其阳性率。结果妊娠期高血压疾病患者Cys-C、BUN、肌酐均高于对照组(P<0.05)。妊娠期高血压疾病轻度组患者Cys-C、肌酐高于对照组(P<0.05),但BUN与对照组差异无统计学意义(P>0.05)。妊娠期高血压疾病中度、重度组患者Cys-C、BUN、肌酐均不同程度高于对照组(P<0.05)。妊娠期高血压疾病轻度组的Cys-C阳性率高于BUN、肌酐的阳性率(P<0.05);中度、重度组Cys-C阳性率亦明显高于BUN、肌酐的阳性率。结论 Cys-C、BUN、肌酐均可反映妊娠期高血压疾病患者肾损害的情况,但Cys-C在早期的诊断价值优于BUN、肌酐,可作为妊娠期高血压疾病预防及早期治疗的动态监测指标。

Objective To investigate the diagnostic value of serum cystatin-C （Cys-C） detection in hypertensive disorder complicating pregnancy patients. Methods A hundred patients with pregnancy induced hypertension （PIH） were chosen as the research object from February 2012 to March 2013, and they were divided into mild group, moderate group and severe group according to the severity of the disease. The other 40 healthy pregnant women were selected as the controls （the control group）. We compared the four groups in terms of Cys-C, serum urea nitrogen （BUN） and creatinine level, as well as the positive rate of Cys-C, BUN, and creatinine. Results Cys-C, BUN, and creatinine in the PIH group were significantly higher than those in the control group （P 〈 0.05）. Cys-C and creatinine in preeclampsia mild group were significantly higher than those in the control group （P 〈 0.05）, but BUN level between the two was not statistically significant （P 〉 0.05）. Cys-C, BUN, and creatinine in the PIH moderate and severe groups were significantly higher than those in the control group （P 〈 0.05）. The abnormal rate of Cys-C in the PIH mild group was significantly higher than that of Cys-C and creatinine （P 〈 0.05）. Conclusions Cys-C, BUN and creatinine can all show renal damage in PIH patients, but the Cys-C value in early diagnosis is better than that of BUN and creatinine. It can be used as a monitoring index of pregnancy-induced hypertension prevention and early treatment.