摘要
器官纤维化是多种因素引起的急性或慢性病理变化,如若得不到有效治疗最终会导致器官功能衰竭。近年来,关于microRNA的研究越来越受到重视,尤其是microRNA-21(miR-21),作为一种小分子调节RNA,在多种疾病包括癌症、心血管疾病、器官纤维化等的发生过程中发挥重要作用。本文就miR-21在各种纤维化疾病中的作用作一综述。
Organ fibrosis is acute or chronic pathological changes caused by a variety of factors. Lack of effective treatment will eventually lead to organ failure. In recent years,the study of microRNA receives more and more attention. Especially microRNA-21,as a small molecule regulating RNA,plays an important role in the occurrence of a variety of diseases,including cancer,cardiovascular disease,organ fibrosis. This paper reviewed microRNA-21 in various fibrotic diseases.
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2014年第5期638-641,共4页
Journal of Chongqing Medical University
基金
重庆市教委基金资助项目(编号:KJ110304)