MicroRNA-21在器官纤维化中的研究现状

MicroRNA-21 in organ fibrosis

器官纤维化是多种因素引起的急性或慢性病理变化,如若得不到有效治疗最终会导致器官功能衰竭。近年来,关于microRNA的研究越来越受到重视,尤其是microRNA-21(miR-21),作为一种小分子调节RNA,在多种疾病包括癌症、心血管疾病、器官纤维化等的发生过程中发挥重要作用。本文就miR-21在各种纤维化疾病中的作用作一综述。

Organ fibrosis is acute or chronic pathological changes caused by a variety of factors. Lack of effective treatment will eventually lead to organ failure. In recent years,the study of microRNA receives more and more attention. Especially microRNA-21,as a small molecule regulating RNA,plays an important role in the occurrence of a variety of diseases,including cancer,cardiovascular disease,organ fibrosis. This paper reviewed microRNA-21 in various fibrotic diseases.