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骨髓造血微环境对造血干细胞自我更新的调控 被引量：3

Regulation of bone marrow microenvironment on hematopoietic stem cell self-renewal
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摘要 为确保骨髓的终身造血,造血干细胞（HSC）在不断分化生成造血祖细胞（MPP）的同时,还通过自我更新来维持其自身数量不变.这种HSC的自我更新依赖于其所在骨髓微环境（龛）的调控和维持.全面揭示骨髓微环境调控HSC自我更新的机制不但为我们建立更有效的HSC体外扩增体系提供直接依据,同时将为探讨包括白血病和再生障碍性贫血等难治性血液系统疾病的发病机制提供重要信息.
作者 孙洁文 胡成龙 章骏 李静
机构地区 上海师范大学生命与环境科学学院干细胞实验室
出处 《中华血液学杂志》 CAS CSCD 北大核心 2014年第6期571-574,共4页 Chinese Journal of Hematology
基金 国家973项目（2013CB966803）
关键词 骨髓造血微环境 细胞自我更新 造血干细胞 微环境调控 再生障碍性贫血 血液系统疾病 造血祖细胞 骨髓微环境
分类号 R329.2 [医药卫生—人体解剖和组织胚胎学]
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同被引文献19

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中华血液学杂志
2014年 第6期

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