红细胞分泌与镇痛作用的研究进展

Research progress on the secretory and analgesic effects of erythrocytes

人体的红细胞(RBC)内几乎没有细胞器,血红蛋白约占RBC内蛋白质总量的98%,是主要的气体转运媒介。以往的研究数据表明,RBC不仅具有气体交换的功能,在血液循环中还具有产生分子信号的功能。近期有研究表明,蛋白酶体及其亚单位一直存在于成熟的RBC内。RBC内的蛋白酶体与血红蛋白衍生物血衍吗啡肽(Hemorphins)具有很大的关联。不同种类Hemorphins的分泌均源自于RBC内血红蛋白的降解,且通过血液循环对于整个机体产生生理和病理生理学上的作用。本文就RBC分泌的功能、主要产物及作用、产物在临床中的应用进行综述,为临床治疗疼痛开辟新方向。

There is almost no organelle in human red blood cell（RBC）. Hemoglobin approximately accounts for 98% of the RBC protein,serving as the main transport medium of air. The accumulated data indicatd that,RBC not only engaged in air exchange,but also produced molecular signaling as a side job in the circulation of blood. A recent study showed that proteasome and its subunits exist in mature RBC,which is involved in the formation of hemorphins. Different types of hemorphins are derived from the degradation of hemoglobin in RBC,which have a systemic physiological and pathophysiological influences when they travel through the body via the bloodstream. In this paper,we reviewed the secretory function of red blood cells,the main products and their function,and their clinical applications,hoping to open up a newdirection for the clinical treatment of pain in the future.