期刊文献+

Aurora-A和EGFR联合表达与肺腺癌侵袭转移的相关性研究 被引量:2

The expression correlation of Aurora-A and EGFR in lung adenocarcinoma
原文传递
导出
摘要 目的探讨Aur-A和表皮生长因子受体(EGFR)在肺腺癌组织中的表达及其与临床病理特征的关系。方法用免疫组化方法检测105例肺腺癌组织中Aur-A与EGFR的表达,并与临床病理因素进行相关性分析。结果 Aur-A在肺腺癌组织中的阳性率为71.4%(75/105)。Aur-A与EGFR表达呈正相关(r=0.416,P<0.05),Aur-A的表达与临床分期、淋巴结转移相关(P<0.05),Aur-A与EGFR的共表达与淋巴结转移有关(P<0.05)。结论 Aur-A阳性表达可作为评价肺腺癌发生发展的生物学指标,联合EGFR检测更有助于肺腺癌侵袭转移的判断。 Objective This study was designed to investigate the expression of Aurora-A (Aur-A) and epidermal growth factor receptor (EGFR), and the clinicopathological significance of Aur-A and EGFR in patients with resected lung adenocarcinoma. Methods The protein expression of Aur-A and EGFR in 105 lung adenocarcinoma tissues were assessed by Immunohistochemistry (IHC), and their correlations with clinicopathological features were statistically analyzed. Results The over-expression rate of Aur-A was 71.4% (75/105). A positive correlation between Aur-A over-expression rate and ascending pathological stages was observed (P〈0.05). In addition, the expression of Aur-A had a positive correlation with EGFR (P〈0.001). The co-expression of Aur-A and EGFR related to node metastasis status (P〈0.05). Conclusion The expression of Aur-A could be considered as a biological marker to estimate the progression of lung adenocarcinoma. Combine detection of EGFR may help to judge the metastasis of lung adenocarcinoma.
出处 《热带医学杂志》 CAS 2014年第5期585-588,F0002,共5页 Journal of Tropical Medicine
基金 广东省科技计划项目(2009B060700036)
关键词 肺腺癌 AURORA-A 表皮生长因子受体 淋巴结转移 lung adenocarcinoma Aurora-A epidermal growth factor receptor lymph node metastasis
  • 相关文献

参考文献15

  • 1Kratz JR, He J, Van Den Eeden SK, et al. A practical molecular assay to predict survival in resected non-squamous, non-small-cell lung cancer: development and international validation studies [ J ]. Lancet,2012,379(9818) : 823-832.
  • 2Fu J, Bian M, Jiang Q,et al. Roles of Aurora kinases in mitosis and tumorigenesis [ J ]. Mol Cancer Res, 2007,5 ( 1 ) : 1-10.
  • 3许州,袁先厚,江普查,陈锋,宫睿.Aurora A、PCNA在脑胶质瘤中的表达及临床意义[J].武汉大学学报(医学版),2010,31(2):227-229. 被引量:4
  • 4Landen CN Jr, Lin YG,Immaneni A,et al. Overexpression of the centrosomal protein Aurora-A kinase is associated with poor prognosis in epithelial ovarian cancer patients [ J ]. Clin Cancer Res,2007,13(14) : 4098-4104.
  • 5王新平,李国庆.Aurora-A和Aurora-B在人胃癌组织中的表达及意义[J].中国现代医药杂志,2010,12(12):26-28. 被引量:6
  • 6Xu J, Wu X, Zhou WH, et al. Aurora-A identifies early recurrence and poor prognosis and promises a potential therapeutic target in triple negative breast cancer [ J ]. PLoS One, 2013,8 (2) : e56919.
  • 7Ogawa E, Takenaka K, Katakura H, et al. Perimembrane Aurora-A expression is a significant prognostic factor in correlation with proliferative activity in non-small-cell lung cancer (NSCLC) [J]. Ann Surg Oncol, 2008,15 (2) : 547-554.
  • 8Gritsko TM,Coppola D,Paciga JE,et al. Activation and overexpressian of centrosome kinase BTAK/Aurora-A in human ovarian cancer[J]. Clin Cancer Res, 2003,9(4) : 1420-1426.
  • 9Wu JC, Chen TY, Yu CT, et al. Identification of V23RalA-Ser194 as a critical mediator for Aurora-A-induced cellular motility and transformation by small pool expression screening [J]. J Biol Chem, 2005,280(10) : 9013-9022.
  • 10Guan Z, Wang XR, Zhu XF, et al. Aurora-A, a negative prognostic marker, increases migration and decreases radiosensitivity in cancer cells [ J ]. Cancer Res, 2007,67 ( 21 ) : 10436-10444.

二级参考文献11

  • 1刘芳,冯贤松.AURORA-A在肝恶性肿瘤中的表达及意义[J].腹部外科,2004,17(6):373-374. 被引量:2
  • 2Xiao Xia Wang,Rong Liu,Shun Qian Jin,Fei Yue Fan,Qi Min Zhan.Overexpression of Aurora-A kinase promotes tumor cell proliferation and inhibits apoptosis in esophageal squamous cell carcinoma cell line[J].Cell Research,2006,16(4):356-366. 被引量:24
  • 3关中,陈福进,陈艳峰,李秋梨,田慎之,孙传政.Aurora-A在喉鳞癌中表达的临床意义[J].中山大学学报(医学科学版),2006,27(6):699-703. 被引量:2
  • 4Dutertre S, Descamps S, Prigent C. On the role of aurora-A in eentrosome function[J]. Oncogene, 2002, 21 (40): 6 175-6 183.
  • 5Kelman Z. PCNA: structure, functions and interactions[J]. Oncogene, 1997, 14(6): 629-640.
  • 6Stenoien DL, Sen S, Mancini MA, et al. Dynamic association of a tumor amplified kinase, Aurora-A, with the centrosome and mitotic spindle[J]. Cell Motil Cytoskeleton, 2003, 55(2):134-146.
  • 7Reiter R, Gais P, Jutting U, et al. Aurora kinase a messenger RNA overexpression is correlated with tumor progression and shortened survival in head and neck squamous cell carcinoma[J]. Clin Cancer Res, 2006, 12(17): 5 136-5 141.
  • 8Anand S, Penrhyn-Lowe S, Venkitaraman AR. Aurora A amplification overrides themitotic spindle assembly checkpoint, inducing resistance to Taxol[J]. Cancer Cell, 2003, 3(1): 51-62.
  • 9D'Assoro AB, Lingle WL, Salisbury JL, et al. Centrosome amplification and the development of cancer [J]. Oncogene, 2002, 21(40): 6 146-6 153.
  • 10Peschos D, Stefanou D, Vougiouklakis T, et al. Cell cycle proteins in laryngeal cancer: role in proliferation and prognosis[J]. J Exp Clin Cancer Res, 2005, 24: 431-437.

共引文献8

同被引文献22

  • 1张洁莉,孙昭,霍真,罗玉凤,马水清,王德田,曹金伶,杨缇,崔全才,白春梅.头颈部鳞癌人乳头状瘤病毒16/18感染状态与Ki-67、P53表达的关系[J].中国医学科学院学报,2010,32(4):429-432. 被引量:13
  • 2Salazar N,Munoz D,Singh RK,et al. The heterotypic interac-tion between CXCR7 and EGFR is an alternative proliferationmechanism in breast cancer[J]. Cancer Res,2014,74(19 Sup-plement) :3336-3336.
  • 3Gaule PB,Crown J,QDonovan N,et al. cMET in triple-nega-tive breast cancer: is it a therapeutic target for this subset ofbreast cancer patients. [J]. Expert Opin Ther Tar,2014,18(9): 999-1009.
  • 4Volinia S,Nuovo G,Drusco A, et al. Pluripotent stem cellmiRNAs and metastasis in invasive breast cancer [J]. J NatCancer Ins, 2014,106(12): 324-331.
  • 5Lange JM, Takashima JR, Peterson SM,et al. Breast cancer in femalesurvivors of Wilms tumor: A report from the National Wilms Tlimorlate effects study[J]. Cancer, 2014, 120(23) : 3722-3730.
  • 6Giles KM, Brown RAM, Epis MR, et al. miRNA-7-5p inhibitsmelanoma cell migration and invasion [J]. Biochem Bioph ResComm, 2013,430(2): 706-710.
  • 7Liu Z, Liu Y,Li L,et al. MiR-7-5p is frequently downregulatedin glioblastoma microvasculature and inhibits vascular endothelialcell proliferation by targeting RAF1[J]. Tumor Biology, 2014,35(10):10177-10184.
  • 8Mader CC, Oser M,Magalhaes MAO, et al. An EGFR-Src-Arg-cortactin pathway mediates functional maturation of inv-adopodia and breast cancer cell invasion[J]. Cancer Res, 2011,71(5): 1730-1741.
  • 9许建功,蔡瑞君,熊刚,王武军.高危型HPV感染与食管鳞癌组织中HLA-G表达的相关性研究[J].热带医学杂志,2012,12(2):144-147. 被引量:4
  • 10彭学勤,甘润良.肿瘤病毒的发现历程及在肿瘤发生机制中的研究意义[J].现代生物医学进展,2012,12(18):3596-3600. 被引量:4

引证文献2

二级引证文献6

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部