肺炎支原体感染与儿童哮喘的相关性和临床疗效分析

An analysis on the correlation and clinical effects of Mycoplasma pneumoniae infection and pediatric asthma

目的探讨肺炎支原体(MP)感染与儿童哮喘的相关性并对其临床疗效进行分析。方法选取2010年3月至2013年10月在湖北省妇幼保健院诊治的141例儿童哮喘患者为观察组,选择同期上呼吸道感染患儿139例为对照组,检测MP-IgM,分析肺炎支原体感染与儿童哮喘的相关性;同时对肺炎支原体感染诱发的儿童哮喘进行对症+阿奇霉素序贯疗法+雾化吸入(观察A组单独使用沙丁胺醇雾化吸入,观察B组使用沙丁胺醇联合异丙托溴铵雾化吸入)治疗,分析疗效。结果儿童哮喘组MP-IgM的阳性率(43.26%)明显高于上呼吸道感染组(12.23%),差异有统计学意义(χ2=33.541,P<0.05)。观察A组和观察B组在疗效总有效率、气促缓解时间、最大峰流速值之间差异无统计学意义(P>0.05);在咳嗽、肺部啰音缓解时间上观察B组的疗效优于观察A组,差异有统计学意义(P<0.05)。结论肺炎支原体感染与儿童哮喘相关,为诱发病因之一。治疗上应及时加用大环内酯类抗生素控制感染,雾化吸入沙丁胺醇加用异丙托溴铵,联合用药疗效好于单一用药。

Objective Discuss the correlation between Mycoplasma pneumoniae infection and pediatric asthma and analyze its clinical effects. Methods 141 pediatric asthma cases in our hospital from March 2010 to October 2013 were chosen as the observation group and 139 cases of patient children with URI as a control group to test MP-IgM and analyze the correlation between Mycoplasma pneumoniae infection and pediatric asthma. Pediatric asthma patients were treated with azithromycin sequential therapy ＋ aerosol inhalation. （Observe Group A for sole aerosol inhalation of salbutamol and observe Group B for aerosol inhalation of salhutamol and ipratropium bromide）. Results The positive rate of MP-IgM in pediatric asthma group was significantly higher than the URI group （X^2=33.541, P〈0.05）. No statistical significant differences were found in the total effective rate, anhelation remission time and maximum peak expiratory flow rate between Group A and Group B （P〉0.05） ; as for the curative effect in remission time for coughing and lung rale, Group B was better than Group A with a statistical significance in their difference （P〈0.05）. Conclusion Mycoplasma pneumoniae infection is related to pediatric asthma as one of the triggers ; in its treatment, macrolides antibiotics should be increased timely to put infection under control; the aerosol inhalation of salbutamol with ipratropium bromide can bring a better curative effect than that with only one drug.